Title:
ALUMINUM NANOCRYSTALLINE COMPOSITE IMMUNE DRUG AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/155861
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biomedicines and vaccines, and in particular to an aluminum nanocrystalline composite immune drug and a preparation method therefor and use thereof. The aluminum nanocrystalline is used as a carrier, the surface of the aluminum nanocrystalline is covered with polyethylene glycol, and functional polypeptide sequences and cytokine molecules are linked by a polyethylene glycol end group to form a virus-like particle immune drug. According to the drug, the cytokine stability and the tumor tissue retention time are improved, and the auxiliary anti-tumor effect of the cytokines is effectively improved.
Inventors:
WANG YALING (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
Application Number:
PCT/CN2023/076660
Publication Date:
August 24, 2023
Filing Date:
February 17, 2023
Export Citation:
Assignee:
THE GBA NAT INSTITUTE FOR NANOTECHNOLOGY INNOVATION (CN)
International Classes:
A61K38/06; A61K47/52; A61K38/12; A61K38/19; A61K38/20; A61K47/60; A61K47/69; A61P35/00
Foreign References:
| CN114522241A | 2022-05-24 | |||
| CN104587464A | 2015-05-06 | |||
| CN111671894A | 2020-09-18 | |||
| CN112704734A | 2021-04-27 |
Other References:
SACCHI ANGELINA, GASPARRI ANNA MARIA, MONIERI MATTEO, ANDERLUZZI GIULIA, COLOMBO BARBARA, GORI ALESSANDRO, CORTI ANGELO, CURNIS FL: "Nanogold Functionalized With Lipoamide-isoDGR: A Simple, Robust and Versatile Nanosystem for αvβ3-Integrin Targeting", FRONTIERS IN CHEMISTRY, vol. 9, 28 May 2021 (2021-05-28), pages 690357, XP093085970, DOI: 10.3389/fchem.2021.690357
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW CO., LTD. (CN)
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