Title:
ALUMINUM NANOCRYSTAL DELIVERY SYSTEM, AND SELF-ASSEMBLED PARTICLE ADJUVANT VACCINE BASED ON BINDING OF ALUMINUM NANOCRYSTAL DELIVERY SYSTEM AND VACCINE ANTIGEN MOLECULE
Document Type and Number:
WIPO Patent Application WO/2023/134783
Kind Code:
A3
Abstract:
The present invention relates to the technical field of biomedicine technology and vaccines, and particularly relates to an aluminum nanocrystal delivery system with a surface covered with an Fc affinity protein and a preparation method for a self-assembled particle adjuvant vaccine. An aluminum nanocrystal is used as a carrier, the surface of the aluminum nanocrystal is covered with an Fc affinity protein molecular layer and an antigen molecule, and the antigen of a recombinant Fc Tag specifically binds to an Fc affinity protein, so that antigen self-assembly is realized, a virus-like particle vaccine is formed, and the antigen density is improved. The present vaccine can generate a high-titer specific antibody by inducing a body fluid and cell immunity.
Inventors:
WANG YALING (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
CHEN CHUNYING (CN)
ZHAO YULIANG (CN)
Application Number:
PCT/CN2023/080897
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
THE GBA NAT INSTITUTE FOR NANOTECHNOLOGY INNOVATION (CN)
International Classes:
B82Y5/00; A61K39/385; A61K39/39; A61P37/04; B82Y40/00
Domestic Patent References:
| WO2021198288A1 | 2021-10-07 |
Foreign References:
| CN114366809A | 2022-04-19 | |||
| CN111741767A | 2020-10-02 | |||
| CN112791181A | 2021-05-14 | |||
| CN106692963A | 2017-05-24 | |||
| US20220001006A1 | 2022-01-06 |
Other References:
ZRAZHEVSKIY PAVEL, GAO XIAOHU: "Quantum dot imaging platform for single-cell molecular profiling", NATURE COMMUNICATIONS, vol. 4, no. 1, XP093091327, DOI: 10.1038/ncomms2635
WANG TING, ZHEN YUANYUAN, MA XIAOYU, WEI BIAO, WANG NING: "Phospholipid Bilayer-Coated Aluminum Nanoparticles as an Effective Vaccine Adjuvant-Delivery System", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 7, no. 12, 1 April 2015 (2015-04-01), US , pages 6391 - 6396, XP093091328, ISSN: 1944-8244, DOI: 10.1021/acsami.5b00348
WANG TING, ZHEN YUANYUAN, MA XIAOYU, WEI BIAO, WANG NING: "Phospholipid Bilayer-Coated Aluminum Nanoparticles as an Effective Vaccine Adjuvant-Delivery System", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 7, no. 12, 1 April 2015 (2015-04-01), US , pages 6391 - 6396, XP093091328, ISSN: 1944-8244, DOI: 10.1021/acsami.5b00348
Attorney, Agent or Firm:
YOGO PATENT AND TRADEMARK AGENCY LIMITED COMPANY (CN)
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