ADENO-ASSOCIATED VIRUS VECTORS AND METHODS OF THEIR USE FOR REDUCING THE RISK OF, TREATING, AND PREVENTING METASTASIS

Title:

ADENO-ASSOCIATED VIRUS VECTORS AND METHODS OF THEIR USE FOR REDUCING THE RISK OF, TREATING, AND PREVENTING METASTASIS

Document Type and Number:

WIPO Patent Application WO/2024/026319

Kind Code:

A3

Abstract:

The disclosure provides recombinant adeno-associated viral (rAAV) vectors expressing a bispecific fusion protein that binds GD2 and CD3, and methods of using the same for reducing the risk of, preventing, or treating metastasis. The disclosure also provides rAAV vectors for expressing the bispecific fusion protein.

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Inventors:

CRIPE TIMOTHY P (US)
GYULAY LANDON (US)
KASPAR BRIAN (US)
KASPAR ALLAN (US)
VARMA SAMIT (US)
GARDINIER SCOTT JACOB (US)

Application Number:

PCT/US2023/070964

Publication Date:

April 18, 2024

Filing Date:

July 25, 2023

Export Citation:

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Assignee:

VIRONEXIS BIOTHERAPEUTICS INC (US)

International Classes:

A61K39/395; C07K16/28; C12N15/113; C12N15/864

Domestic Patent References:

WO2021242848A1	2021-12-02
WO2021154839A1	2021-08-05
WO2021048724A1	2021-03-18

Foreign References:

US20160032009A1	2016-02-04
US20160168211A1	2016-06-16

Attorney, Agent or Firm:

DUSABAN GONZALES, Stephanie et al. (US)

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