Title:
切り詰められたEGFレセプター
Document Type and Number:
Japanese Patent JP2004500902
Kind Code:
A
Abstract:
The present invention relates to truncated EGF receptor molecules that exhibit increased binding affinities for EGFR ligands such as EGF and TGF1. The present invention also relates to methods of screening for EGF receptor ligands and methods of treatment which involve the use of these molecules.
Inventors:
Colin Wesley Ward
Nail Morton McKern
George Oscar Lovrex
Robert Nicholas Jolisen
Thomas Peter John Garrett
Thomas Charles Elman
Antony Wilkes Burgess
Timothy Edward Adams
Theresa Ann Domagala
Eduard Nice
Nail Morton McKern
George Oscar Lovrex
Robert Nicholas Jolisen
Thomas Peter John Garrett
Thomas Charles Elman
Antony Wilkes Burgess
Timothy Edward Adams
Theresa Ann Domagala
Eduard Nice
Application Number:
JP2002506192A
Publication Date:
January 15, 2004
Filing Date:
June 28, 2001
Export Citation:
Assignee:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION
International Classes:
A61K38/22; A61P17/06; A61P35/00; A61P43/00; C07K14/71; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/02; C12N15/09; (IPC1-7): C12N15/09; A61K38/22; A61P17/06; A61P35/00; A61P43/00; C07K14/71; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02
Foreign References:
| WO1991003489A1 | 1991-03-21 | |||
| WO1999062955A1 | 1999-12-09 | |||
| US5708156A | 1998-01-13 | |||
| US5218090A | 1993-06-08 |
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro