【発明の名称】尿素誘導体及びチオ尿素誘導体とその製造方法

Japanese Patent JPH08511269

A

The invention provides a compound of formula (I), wherein Y is an aryl or heteroaryl group substituted by a group chosen from amino, C1-C6 monoalkylamino, 3-pyrrolin-1-yl, pyrrolidin-1-yl, morpholin-4-yl and piperidin-1-yl, the aryl or heteroaryl being optionally substituted in addition by 1 to 3 substituents independently chosen from halogen, C1-C6 alkyl, trihalo-C1-C3 alkyl, hydroxy, C1-C6 alkoxy, C1-C6 alkylthio and C1-C6 alkylsulfonyl; m is zero, 1 or 2; X is oxygen or sulphur; R1 and R2 are each, independently, a C1-C6 alkyl group or R1 and R2 taken together form a C2-C4 alkylene chain in which each carbon atom is optionally substituted by 1 or 2 substituents independently chosen from halogen and C1-C4 alkyl; n is 1, 2 or 3; Q is oxygen or sulphur; W is an aryl or heteroaryl group unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, C1-C6 alkyl, trihalo-C1-C3 alkyl, C1-C6 alkoxy, C1-C6 alkylthio and C1-C6 alkylsulfonyl; or a pharmaceutically acceptable salt thereof. The compounds of the invention show inhibitory activity of the enzyme acyl CoA: cholesterol acyltransferase (ACAT-EC 2.3.1.26) and thus have utility as antiatherosclerotic and antidyslipidaemic agents and in the prevention of coronary heart disease.

JP2005502623	Substituted piperazine and diazepan
WO/1997/010819	TREATING NIDDM WITH RXR AGONISTS

Cottage, paolo
Funelli, Daniele
Severino, Deino
Chiari, August
Gizetsuri, Giancarlo

JP50551294A

November 26, 1996

June 24, 1994

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Falmatia Esset Pear

C07D317/30; A61K31/38; A61K31/40; A61K31/4025; A61K31/505; A61K31/535; A61P9/08; A61P9/10; C07D317/28; C07D319/06; C07D339/06; C07D405/10; C07D409/10; C07D413/10; (IPC1-7): C07D317/30; A61K31/38; A61K31/40; A61K31/505; A61K31/535; C07D319/06; C07D339/06; C07D405/10; C07D409/10; C07D413/10

Yoshio Kawaguchi (2 outside)

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