Title:
残留溶媒抽出方法および同により生成される微粒子
Document Type and Number:
Japanese Patent JP5841565
Kind Code:
B2
Abstract:
Methods for preparing microparticles having reduced residual solvent levels are disclosed. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Inventors:
Ricky, Michael, Yi.
Ram Stack, J., Michael
Kumar, Rajesh
Ram Stack, J., Michael
Kumar, Rajesh
Application Number:
JP2013129973A
Publication Date:
January 13, 2016
Filing Date:
June 20, 2013
Export Citation:
Assignee:
Arcams Pharma Ireland Limited
International Classes:
A61K38/00; B65D5/462; A61K9/16; A61K31/519; A61K38/04; A61K38/22; A61K47/32; A61K47/34; B01J8/02; B01J13/08; B01J13/12; B01J13/20; B01J14/00; B01J19/12; B01J19/24; B65D5/46; B65D5/465; B65D71/00; B65D71/36
Domestic Patent References:
| JP7309897A | ||||
| JP57093912A | ||||
| JP54055717A | ||||
| JP57118512A | ||||
| JP4505454A | ||||
| JP11506764A | ||||
| JP4506931A | ||||
| JP9505308A | ||||
| JP2001517615A |
Foreign References:
| WO1989003678A1 | ||||
| WO1999047588A1 | ||||
| WO1999015154A1 |
Other References:
THOMASIN C,EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,NL,ELSEVIER SCIENCE PUBLISHERS B.V.,1996年,V42N1,P16-24
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki