To provide a reaction device for an organic substance, or the like, by a supercritical fluid, or the like, capable of certainly the sealing supercritical fluid of a high pressure or a subcritical fluid in a cylinder in a reaction engine.

In the reaction engine 2, compression fluid vapor with the substance to be reacted introduced into the cylinder is compressed by operating a compression plunger 4, and after a chemical reaction of the compressed reaction substance to be reacted is completed, the compression plunger 4 is operated in a reverse direction to reduce the temperature and pressure of the fluid vapor, and an intake/exhaust stroke is periodically carried out by removing out the fluid containing the product from the cylinder 3 and blowing-in the fluid vapor into the cylinder. Seal members 15, or the like, are provided on a lower part of a slide surface of the cylinder 3 and the compression plunger 4, and a liquid is poured to a border part 3b formed by the slide surface of the cylinder 3, an outer periphery of the plunger 4 and the both seal members 15, or the like. A liquid press-feed pump 19 for enhancing sealing property and inhibiting abrasion of the slide surface of the cylinder 3 and the sealing member 15, or the like, to a low degree is also provided to the reaction engine 2.

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