PURPOSE: To efficiently produce an optically active β-substituted glutaric acid monoester, by alcoholizing a β-substituted glutaric acid anhydride in the presence of an aliphatic alcohol in an organic solvent containing an enzyme suspended therein,.
CONSTITUTION: A β-substituted glutaric acid anhydride expressed by formula I (R is hydrogen, halogen or substituted or unsubstituted aliphatic hydrocarbon group or substituted or unsubstituted aromatic hydrocarbon group or at least one kind of substituent group containing a hetero-atom., such as oxygen, nitrogen or sulfur) is alcoholized in the presence of an aliphatic alcohol expressed by the formula Z-OH (Z is 1W10C straight-chain or branched chain alkyl) in an organic solvent, such as n-hexane, toluene, diethyl ether or n-dibutyl ether, containing an enzyme, such as lipase or esterase, suspended therein to afford the aimed optically active glutaric acid monoester expressed by formula II or III.
AMANO MASAKI
TODA HARUHIKO
