Title:
NEW ENZYME FOR ESTERIFICATION OF CHOLESTEROL AND ITS USE
Document Type and Number:
Japanese Patent JP2004337165
Kind Code:
A
Abstract:
To provide a technology applicable for amelioration of state of the skin (prevention and amelioration of dry rough skin, prophylaxis, prevention, of melasma, wrinkle, etc.) or treatment of hyperlipidemia, etc., by developing a technology controlling amount of free fatty acids and cholesterol in the body.
The new cholesterol esterifying enzymes catalyze cholesterol producing reaction (transfer of an acyl group), without mediating action of coenzyme, by acting free fatty acids and cholesterol or its derivatives as substrates, not acting on fatty acid-CoA complex. The enzyme has 40-45 kDa of molecular weight (gel filtration technique), 3.0-7.0 of acting pH, 4.0-5.0 of optimal pH, acting at 4-60°C, 20-50°C of optimal temperature.
Inventors:
IIDA TOSHIMOCHI
YOSHIDA SEIICHI
TOJO YOSUKE
AOKI HIROFUMI
TSUNENAGA MAKOTO
INOMATA SHINJI
DENDA MITSUHIRO
YOSHIDA SEIICHI
TOJO YOSUKE
AOKI HIROFUMI
TSUNENAGA MAKOTO
INOMATA SHINJI
DENDA MITSUHIRO
Application Number:
JP2004127437A
Publication Date:
December 02, 2004
Filing Date:
April 22, 2004
Export Citation:
Assignee:
SHISEIDO CO LTD
International Classes:
G01N33/15; A61K8/00; A61K8/66; A61K8/96; A61K38/43; A61P3/06; A61P17/16; A61Q19/00; C12N9/10; C12P33/00; (IPC1-7): C12N9/10; A61K7/00; A61K7/48; A61K38/43; A61P3/06; A61P17/16; C12P33/00; G01N33/15
Attorney, Agent or Firm:
Yoko Hasegawa
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