複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法

Japanese Patent JP5021466

B2

In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In the process the prior art 5-pump arrangement is replaced by a 4-pump arrangement. The process employs a single eluent constant flow feed pump and a single eluent compensation vessel and no circulation pump. The assembly employs no more than four pumps in the chromatography circuit. The prior art discharge pump, extract or refined discharge is replaced by a regulator valve. The automatic discharge of impure eluent in the circuit is facilitated by on-line detection and a regulator valve. Measurements made of the recyclate flow and the associated redundancy is increased by data comparison, increasing precision of the volumetric flow control. Independent claims are included for: (1) a modular valve system with a master plate, a valve housing, and a control unit housing, where the control system is located within an interior pneumatic chamber; and (2) a commensurate production process.

Jochen Struve
Karsten-Ullrich Kratt
Gerhard Nate
Jern Greifenberg
Sebastian becker
Heinz Kancy
Peter Yane
Berthold Justin

JP2007517065A

September 05, 2012

May 14, 2005

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Bayer Technology Services GmbH

G01N30/42; B01D15/00; B01D15/08; B01D15/18; F16B11/00; F16D1/068; F16D3/38; G01N30/26; G01N30/46; G01N30/88

JP8229306A
JP3172688A
JP11228455A
JP9206502A
JP2004077329A

Samejima Mutsumi
Kyousei Tamura
Haruhiko Ema

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