Title:
メチルコバラミンの精製方法
Document Type and Number:
Japanese Patent JP6867409
Kind Code:
B2
Abstract:
The present invention relates to a process for the purification of methylcobalamin, namely from iron cyanide impurities, comprising contacting a solution comprising methylcobalamin and iron cyanide anions with a strongly basic anion exchange resin. This purification process can advantageously be used for removing iron cyanide impurities from methylcobalamin obtained by reductive methylation of cyanocobalamin and wherein iron (II) salts are used as cyanide scavengers, thus providing methylcobalamin with a reduced iron content. Methylcobalamin (R is methyl).
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Inventors:
Salares Rossell, Juan
Marquillas Orondric, Francisco
Marquillas Orondric, Francisco
Application Number:
JP2018558675A
Publication Date:
April 28, 2021
Filing Date:
March 30, 2017
Export Citation:
Assignee:
Health Tech Bioactives, S.L.U.
International Classes:
C07H23/00; B01J41/05; B01J47/02; B01J47/14; B01J49/07; B01J49/57; C07H1/06
Domestic Patent References:
| JP49017280B1 | ||||
| JP50041900A | ||||
| JP45038059B1 | ||||
| JP51000120B1 | ||||
| JP62056491A |
Foreign References:
| GB1306958A | ||||
| WO2002098896A1 | ||||
| WO2001042271A1 |
Attorney, Agent or Firm:
Asamura patent office