Title:
HETEROARYL COMPOUNDS FOR KINASE INHIBITION
Document Type and Number:
Japanese Patent JP2019194217
Kind Code:
A
Abstract:
To provide heteroaryl compounds for kinase inhibition.SOLUTION: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein. Compounds that are capable of inhibiting mutant EGFR proteins, e.g., EGFR having one or more mutations in the exon 20 domain are also described herein. In some embodiments, compounds disclosed herein selectively inhibit mutant EGFR, such as EGFR having one or more exon 20 mutations, in comparison to a wild-type EGFR.SELECTED DRAWING: None
Inventors:
HUANG WEI-SHENG
GONG YONGJIN
LI FENG
NICHOLAS E BENCIVENGA
DAVID C DALGARNO
ANNA KOHLMANN
WILLIAM C SHAKESPEARE
RANNY M THOMAS
ANGELA V WEST
WILLMEN YOUNGSAYE
ZHANG YUN
ZHOU TIANJUN
ZHU XIAOTIAN
GONG YONGJIN
LI FENG
NICHOLAS E BENCIVENGA
DAVID C DALGARNO
ANNA KOHLMANN
WILLIAM C SHAKESPEARE
RANNY M THOMAS
ANGELA V WEST
WILLMEN YOUNGSAYE
ZHANG YUN
ZHOU TIANJUN
ZHU XIAOTIAN
Application Number:
JP2019115443A
Publication Date:
November 07, 2019
Filing Date:
June 21, 2019
Export Citation:
Assignee:
ARIAD PHARMA INC
International Classes:
C07D401/14; A61K31/506; A61K31/53; A61K31/5377; A61P35/00; A61P43/00; B01J23/44; B01J25/02; B01J31/02; B01J31/12; C07D403/04; C07D403/14; C07D405/04; C07D405/14; C07D471/04
Domestic Patent References:
| JP2013544273A | 2013-12-12 |
Foreign References:
| US20120094999A1 | 2012-04-19 | |||
| US20110263541A1 | 2011-10-27 | |||
| WO2009158571A1 | 2009-12-30 | |||
| WO2015195228A1 | 2015-12-23 | |||
| WO2015175632A1 | 2015-11-19 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto