DIAGNOSTIC COMPOUND OF DISEASES ASSOCIATED WITH VCAM EXPRESSION

Title:

DIAGNOSTIC COMPOUND OF DISEASES ASSOCIATED WITH VCAM EXPRESSION

Document Type and Number:

Japanese Patent JP2014114318

Kind Code:

A

Abstract:

To provide a novel diagnostic compound of diseases associated with vascular cell adhesion molecule-1 (VCAM) expression, to provide a preparation method of the same, and to provide a use of the same in medical imaging.

There is provided a Signal-Link-Peptide that is a peptide comprising VCAM-targeting peptide, the VCAM-targeting peptide being: a compound selected from the group consisting of following peptides a)X1-X2-X3-X4-X5-X6-X7-X8-X9, preferably the peptide NNSKSHT, or b)X10-X11-X12-X13-X14-X15-X16-X17-X18, preferably the peptide CMKTDTRLC, and functional equivalents of the peptides; and a pharmaceutically acceptable salt of the compound a) or b). Furthermore, in the compound, Signal is a chelate that may or may not be coupled to a paramagnetic metal, radionuclide, and the radionuclide for PET imaging is Ga68.

Inventors:

MARC PORT
OLIVIER ROUSSEAUX
ROBERT MULLER
CARMEN BURTEA

Application Number:

JP2014025776A

Publication Date:

June 26, 2014

Filing Date:

February 13, 2014

Export Citation:

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Assignee:

GUERBET SA

International Classes:

C07K11/00; A61K51/00; C12P9/00

Domestic Patent References:

JP2007521254A	2007-08-02
JPH10508315A	1998-08-18

Foreign References:

WO2006037882A1	2006-04-13
WO2003091391A2	2003-11-06

Attorney, Agent or Firm:

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto

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