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Title:
アトピー性皮膚炎モデル非ヒト動物及びその使用
Document Type and Number:
Japanese Patent JP6890834
Kind Code:
B2
Abstract:
An atopic dermatitis model non-human animal, containing a gene mutation in which a complex containing dedicator of cytokinesis 8 (DOCK8) protein, mammalian STE20-like kinase 1 (MST1) protein, and endothelial PAS domain protein 1 (EPAS1) protein is not formed in CD4 + T cells.

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Inventors:
Nobunori Fukui
Kazuhiko Yamamura
Uruno Taketo
Furue Masutaka
Application Number:
JP2018501805A
Publication Date:
June 18, 2021
Filing Date:
February 24, 2017
Export Citation:
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Assignee:
Kyushu University
International Classes:
C12N15/877; A01K67/027; A61K39/00; A61P17/00; C07K14/47; C12N5/10; C12Q1/02; C12Q1/6897
Domestic Patent References:
JP2011516065A
Other References:
植田祥啓,木梨達雄,Mst1による胸腺細胞のインテグリン接着制御と選択機構,医学のあゆみ,2013年11月 9日,Vol. 247, No. 6,p. 565, 566
SU, H. C., et al.,DOCK8 deficiency,ANNALS OF THE NEW YORK ACADEMY OF SCIENCE,2011年,Vol. 1246,p. 26-33
Attorney, Agent or Firm:
Sumio Tanai
Yasushi Matsunuma
Shu Oikawa
Masato Iida



 
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