Title:
ASYMMETRICALLY BRANCHED DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
Document Type and Number:
Japanese Patent JP2021055080
Kind Code:
A
Abstract:
To provide a high-molecular-weight branched, degradable polyethylene glycol derivative which does not cause cell vacuoles.SOLUTION: A branched, degradable polyethylene glycol derivative represented by formula (1) includes an oligopeptide that decomposes intracellularly in each molecule. (In the formula, k1 and k2 are independently 1-12; j1 and j2 are independently 45-950; R is a hydrogen atom, a substituted or unsubstituted C1-12 alkyl group, a substituted aryl group, an aralkyl group, or a heteroalkyl group; Z is an oligopeptide which is degraded by intracellular enzymes; X is a functional group which can react with a biological substance; and L1 and L2 are each independently single bonds or divalent spacers).SELECTED DRAWING: None
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Inventors:
HAMURA TAKESHI
YOSHIOKA HIROKI
OSAKAMA KAZUKI
NISHIYAMA NOBUHIRO
YOSHIOKA HIROKI
OSAKAMA KAZUKI
NISHIYAMA NOBUHIRO
Application Number:
JP2020160392A
Publication Date:
April 08, 2021
Filing Date:
September 25, 2020
Export Citation:
Assignee:
NOF CORP
TOKYO INST TECH
TOKYO INST TECH
International Classes:
C08G65/333; C08G81/00
Attorney, Agent or Firm:
Takashima Ichi
Mitsunori Kamata
Kyoko Doi
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Mitsunori Kamata
Kyoko Doi
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki