Title:
1-ベンジル-4-[(5,6-ジメトキシ-1-インダノン)-2-イル]メチルピペリジンおよびその塩酸塩の製造法
Document Type and Number:
Japanese Patent JP4696062
Kind Code:
B2
Abstract:
Processes for prepering 1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-yl]methylpiperidine (donepezil), which is useful as an intermediate for medicines, and for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (donepezil hydrochloride), which is useful as a medicine. The process for donepezil hydrochloride production comprises catalytically hydrogenating the compound represented by the structural formula (III) [1-benzyl-4-[(5,6-dimethoxy-lindanon)-2-ylidene]methylpiperidine] with a Raney nickel catalyst under mild conditions and subsequently treating it with hydrochloric acid. Thus, impurities are further diminished. The operations are simple and the process is suitable for industrial production.
Inventors:
Akio Imai
Hiroshi Nishimura
Hiroshi Nishimura
Application Number:
JP2006512817A
Publication Date:
June 08, 2011
Filing Date:
April 27, 2005
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
C07D211/32; B01J25/02; A61K31/445; A61P9/00; A61P9/10; A61P25/00; A61P25/14; A61P25/24; A61P25/28; C07B61/00
Domestic Patent References:
| JP2001515480A | 2001-09-18 | |||
| JPS6479151A | 1989-03-24 | |||
| JPH02169569A | 1990-06-29 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Mari Yuge
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Mari Yuge
Yukihiro Ikeda
Naganuma Akio