Document Type and Number:
Japanese Patent JPS6310708
Kind Code:
B2
Abstract:
A chemotherapeutic, antibacterial agent, 7 beta -[(2D-2-amino-2-carboxy)ethylthioacetamido]-7 alpha -methoxy-3-[(1-methyl-1H-tetrazole-5-yl)thiomethyl]-3-cephem-4-carboxylic acid is produced economically and efficiently starting from cephamycin A and/or B by a "new route" process comprising the consecutive steps of reaction of cephamycin with 5-mercapto-1-methyl-1H-tetrazole; protection of the terminal amino group thereof by acylation; protection of the two carboxyl groups thereof by esterification; replacement of the acyl group initially having attached to the 7-amino group by a halogenoacetyl group; deprotection of the blocked 4-carboxyl group; and condensation of D-cysteine with the halogenoacetyl group attaching to the 7-amino group.
Inventors:
IWAMATSU KATSUYOSHI
ITO JIRO
OMOTO SHOJI
TSURUOKA TAKASHI
INOE SHIGEHARU
ITO JIRO
OMOTO SHOJI
TSURUOKA TAKASHI
INOE SHIGEHARU
Application Number:
JP11791179A
Publication Date:
March 08, 1988
Filing Date:
September 17, 1979
Export Citation:
Assignee:
MEIJI SEIKA CO
International Classes:
C07D501/04; C07D501/36; C07D501/57; C12P35/08
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