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WO/2024/046322A1 |
The present disclosure provides agonistic IL-15 complexes that have therapeutic use, and methods for making such proteins. The present disclosure additionally provides methods of treating disease in a subject in need thereof by administe...
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WO/2024/048575A1 |
The present invention provides a novel substance that stably binds to a surface protein which is expressed in NK cells. The present invention provides a monobody that binds to a surface protein of NK cells and that has any one of amino a...
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WO/2024/044850A1 |
Methods for inducing basal cell carcinoma (BCC) or BCC tumors, as well as an inducible non- human animal models of BCC, are defined herein. The methods and animal models comprise targeting Ptch1 and/or a tumor suppressor gene via conditi...
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WO/2024/048688A1 |
The present disclosure provides an opsin that has a light cycle characteristic. Specifically, the present disclosure provides a protein including an amino acid sequence of an opsin, wherein the amino acid sequence of the opsin includes a...
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WO/2024/047188A1 |
The invention relates to methods wherein extraembryonic mesodermal cells (EXCM) are isolated from cell cultures comprising trophoblast stem cells (TSC), by isolating CHD-1 negative EXCM cells from CHD-1 positive TSC.
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WO/2024/048588A1 |
Provided is a novel cell culture system whereby it becomes possible to facilitate the efficiency of the culture of cells. The present invention is a cell culture system (S1) to which a plurality of cell culture devices (100, 200, 300) ar...
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WO/2024/049773A1 |
Disclosed are alveolar organoids which recapitulate important aspects of in vivo lung epithelial regeneration, providing a tractable model to dissect regenerative processes. Clonal expansion of single AEPs generated complex alveolar orga...
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WO/2024/043322A1 |
The present invention addresses the problem of providing: a method which is for producing targe viruses and by which the production amount of the viruses can be improved; and a culture composition containing animal cells, viruses, and a ...
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WO/2024/041618A1 |
The present invention relates to an engineered immune cell co-expressing CD40L. In particular, the engineered immune cell of the present invention is a T cell or an NK cell. According to the present invention, a CAR molecule containing t...
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WO/2024/042267A1 |
The method of the invention for production of a cell-cultured ingestion product comprises the steps of providing parts of a plant and pre-processing the parts in order to obtain a cell culture by cultivation of the cells as a cell suspen...
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WO/2024/041650A1 |
Provided are anti-IL13RA2 single domain antibodies (e.g., VHH domain antibodies), and chimeric antigen receptors (CARs) that binds IL13RA2 comprising same in an extracellular antigen binding domain, a transmembrane domain, and an intrace...
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WO/2024/043202A1 |
The present invention addresses the problem of providing: a method for introducing a nucleic acid into cells, wherein the method can efficiently introduce a high-concentration nucleic acid into high-density cells as a complex of the nucl...
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WO/2024/040519A1 |
Provided is a method of intermittent perfusion fed-batch culture, comprising a fed-batch process including one or more intermittent perfusion phases during the middle to late stage to improve productivity and product quality.
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WO/2024/040681A1 |
The present invention relates to an uPAR-targeted third-generation chimeric antigen receptor, immune effector cells (e.g., T cells, NK cells) engineered to express the chimeric antigen receptor of the present invention, and a use of the ...
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WO/2024/044268A1 |
Methods and compositions for generating human pancreatic beta cells, and the progenitor cells thereof, from human pluripotent stem cells using chemically defined culture media are disclosed. The methods allow for the initial generation o...
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WO/2024/043159A1 |
Provided is a novel cupper efflux oxidase (CueO) variant having improved activity compared to wild types. A protein according to one or more embodiments of the present invention has laccase activity and comprises the amino acid sequence ...
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WO/2024/040980A1 |
Provided are a lentivirus transfection aid and a transfection method. The aid comprises a serum-free medium containing a basic amino acid with a final concentration of 1 mg/mL to 50 mg/mL. This transfection aid can effectively neutralize...
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WO/2024/044721A1 |
Embodiments of the present disclosure provide compositions and methods for injectable recombinant protein-based hydrogels for therapeutic delivery. Embodiments of the composition and methods comprise a recombinant protein, a cell consort...
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WO/2024/040805A1 |
Provided are a nano material for generating ATP and NADPH under red light excitation and a method for preparing the nano material. By means of extracting and nanosizing a plant-derived thylakoid, a nano thylakoid is obtained to generate ...
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WO/2024/042886A1 |
Provided are: a combination of a DNA construct comprising a first site-specific recombinase gene disposed so as to be capable of acting on a promoter of a first gene specific to a specified cell through a DNA construct comprising an n-th...
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WO/2024/044276A1 |
Ballistic microscopy - a completely new approach to " image" a cell utili zing particle bombardment, is described. These are ballistic micro and nano particles that travel through a cell at ballistic speed and capture a pico or femto-lit...
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WO/2023/250499A9 |
The present disclosure provides a chimeric antigen receptor (CAR) molecule comprising a modified hinge and transmembrane domain (HTM-1), wherein the modified hinge and transmembrane domain comprises the amino acid sequence of SEQ ID NO:2...
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WO/2024/044347A1 |
Methods for generating CD31+CD34+CD143+CD309+GATA2+FLI1+RUNX1+vWF+ hemogenic endothelial cells (HECs) are provided using chemically-defined culture media that allow for generating HECs from early mesoderm progenitors in as little as thre...
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WO/2024/041162A1 |
Disclosed are a mesenchymal stem cell and an exosome thereof obtained by treatment of at least two cytokines of IL4, IL21, and IL27, and use thereof, which relate to the technical field of biomedicine. The mesenchymal stem cell and the e...
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WO/2024/041435A1 |
The present invention relates to an anti-Her2/CD3 bispecific antibody specifically activated in a tumor microenvironment. Specifically, provided is a bispecific antibody capable of being chemically conjugated to a substrate that is highl...
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WO/2024/040807A1 |
Disclosed are a cell membrane-based biological material for cross-species cell component delivery and a preparation method. The biological material is based on cell membrane coating, and cross-species cell components are delivered into s...
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WO/2024/040806A1 |
Provided are a biological material for delivering a specific cell-targeted metabolic system, a preparation method therefor, and use thereof. The biological material delivers the specific metabolic system into specific cells by means of m...
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WO/2024/042489A1 |
Compositions including engineered and/or chemically modified transactivating CRISPR RNA (tracrRNA), guide RNA (gRNA), and/or CRISPR RNA (crRNA) are provided. The chemically modified tracrRNA, gRNA, and/or crRNA incorporate bridged nuclei...
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WO/2024/043232A1 |
The purpose of the present invention is to provide a novel therapeutic agent for renal disease. The present invention is a therapeutic agent for renal disease containing a mesenchymal stem cell culture supernatant. The mesenchymal stem...
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WO/2024/042488A1 |
Methods of assessing one or more of T cell differentiation and generation of tolerance of T cell depleted thymus tissue, methods of producing T cell depleted thymus tissue suitable for implantation into a subject, methods of treating a t...
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WO/2024/044726A1 |
The present disclosure relates to compositions and methods for vaccinating a subject against multiple SARS-CoV-2 variants that involves the making and delivery of extracellular vesicles expressing on their surface engineered spike protei...
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WO/2024/044122A1 |
Improved techniques for maintaining long-term cultures of the healthy and diseased human esophagus established in 2-dimension (2D) and 3-dimension is also needed. The invention disclosed herein generally relates to methods and systems fo...
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WO/2024/043521A1 |
The present invention relates to a method for constructing an alveolar organoid using induced pluripotent stem cells derived from alveolar cells, and the like. An alveolar organoid constructed according to the present invention is differ...
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WO/2024/041315A1 |
The present disclosure provides anti-LILRB2 antibodies or antigen-binding fragments thereof, pharmaceutical compositions comprising the same and the uses thereof.
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WO/2024/041579A1 |
Disclosed is a multi-specific antibody targeting CD40 and PD-L1, as well as its use in the treatment of diseases such as tumors.
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WO/2024/043203A1 |
The present invention provides any of modified esterases of (i) to (iii) below. (i) A modified esterase including an amino acid sequence in which at least one amino acid at a site selected from the group consisting of (1) to (5) below ...
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WO/2024/041645A1 |
The present invention relates to the field of biomedicine, in particular to the field of regenerative medicine. Specifically, the present invention relates to a compound for preparing myocardial cells and use thereof, and a method for di...
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WO/2024/044134A1 |
The present invention provides populations of photoreceptor rescue cells (PRC) possessing unique marker profiles and generated by in vitro differentiation from earlier progenitors including pluripotent stem cells and embryonic stem cells...
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WO/2024/038281A1 |
Provided herein is a method of culturing muscles cells for a comestible product, the method seeding muscle cells onto the one or more porous hollow fibres; maintaining the perfusion module in an orientation wherein the one or more porous...
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WO/2024/038182A1 |
The present invention relates to methods of producing hypoimmunogenic functional macrophages, and cell compositions comprising the same. The hypoimmunogenic functional macrophages may be polarised or unpolarised. Such cells may be useful...
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WO/2024/037531A1 |
Provided are an anti-PSMA single-chain antibody, a chimeric antigen receptor associated therewith and use thereof. An amino acid sequence of a heavy chain of the anti-PSMA single-chain antibody includes a sequence shown in SEQ ID NO: 1, ...
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WO/2024/040207A1 |
Genetically engineered NK cells, which express at least one metabolism modulating polypeptides and optionally a chimeric receptor polypeptide (e.g., an antibody-coupled T cell receptor (ACTR) polypeptide or a chimeric antigen receptor (C...
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WO/2024/040013A1 |
Disclosed herein is a three dimensional (3D) culture system for high-throughput screening with pumpless perfusion. It is a two well flow system where one well has a membrane at the bottom and the other is open. Both wells are connected s...
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WO/2024/036387A1 |
The present invention relates to a concentrate of proteins and peptides derived from mesenchymal stem cells that can be used by the pharmaceutical, veterinary, cosmetic or food industries. The protein and peptide concentrate derived from...
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WO/2024/039683A1 |
Compositions and methods for therapeutic use of engineered myeloid cells are described. Methods for increasing therapeutic effectiveness of immune cells by use of an immune cell inhibitory agent prior to therapy is described. Effective u...
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WO/2024/039619A1 |
Embodiments described herein generally provide for expanding cells in a cell expansion system. The cells may be grown in a bioreactor, and the cells may be activated by an activator (e.g., a soluble activator complex). Nutrient and gas e...
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WO/2024/040145A1 |
Systems and methods consistent with the present disclosure relate to MicroOrganoSpheres (MOSs). More particularly, methods relate to delivering components into a MOS. The methods also relate to delivering components into a MOS for screen...
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WO/2024/037011A1 |
Provided are a culture medium and a method for inducing iPSC differentiation to obtain macrophages and use thereof, which relate to the technical field of biopharmaceutics. The culture medium comprises from a first-stage culture medium t...
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WO/2024/037724A1 |
The disclosure provides methods for improving sperm function and fertilizing ability for assisted reproduction techniques. The methods provided by the disclosure, in some embodiments entail sequential changes of temperature, bicarbonate ...
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WO/2024/037461A1 |
Provided are an engineered immune cell and a preparation method therefor. The engineered immune cell is prepared by means of transfecting an isolated nucleic acid molecule. The isolated nucleic acid molecule comprises: a nucleic acid seq...
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