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WO/2001/081910A1 |
Parallel plate slab gel enclosures (slab gel cassettes) used for vertical slab gel electrophoresis are secured to a frame (14) to form a chamber for an upper buffer solution, and the securement is achieved by a pair of clamps (16, 17) th...
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WO/2001/078877A1 |
An electrophoresis system for separating small macromolecules comprising two electrophoretic systems, wherein each system comprises an anode buffer and cathode buffer chamber containing an anode and cathode therein; an ion-permeable sepa...
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WO/2001/078878A1 |
An apparatus for processing compounds in small volumes by electrophoresis, the apparatus comprising: (a) a cathode in a static cathode buffer zone or compartment; (b) an anode in a static anode buffer zone or compartment, the cathode dis...
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WO/2001/078863A1 |
The invention relates to a magnetic filter (30) for removing ferrous particles and the like from a fluid, including a plurality of raised elements (60) extending from a support member in a spaced relationship, which cause ferrous particl...
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WO/2001/076852A1 |
A method and apparatus for the spatial distribution of a filler component within the matrix of a composite material are disclosed. An electric field is applied to a mixture consisting of two or more components that have different dielect...
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WO/2001/069247A2 |
The invention relates to methods of making arrays of anti-ligands for use in the analysis of ligands. Preferred ligands are proteins and preferred anti-ligands are antibodies, or antigen-binding variants or derivatives thereof. The micro...
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WO/2001/069230A2 |
A method is disclosed for effecting the concentration of a polar analyte in an alternating electric field. In the method, a relative translation of the polar analyte and an alternating electric field along a translation path is effected....
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WO/2001/062369A2 |
The invention concerns a composition for use in a process separating constituents in a sample, by electrophoresis on an electrophoresis support, comprising one or several ionic compounds enabling, when an electric field is applied at the...
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WO/2001/061332A1 |
A method of separating compounds that includes the steps of: tagging a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety diffe...
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WO/2001/059440A2 |
A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions a...
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WO/2001/052996A1 |
A method and apparatus for determining the quantity of microorganisms in a sample. The apparatus includes a substrate (10) supporting two pairs of electrodes (4, 6; 4A, 6A) of similar configuration and defining a pair of fluid channels (...
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WO/2001/052997A1 |
A method and apparatus for collecting and separating abiotic and/or biotic particles and/or chemicals in a liquid or gaseous sample. The apparatus includes a substrate (10) supporting at least one pair of electrodes (4, 6) and defining a...
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WO/2001/046459A1 |
The present invention relates to the identification of polyphosphate accumulating organisms that are capable of biologically removing phosphorus from wastewater. Specifically, the invention provides oligonucleotide probes or primers for ...
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WO/2001/040785A1 |
A novel class of capillary electrophoresis probes and a method of employing the same are described. The novel class of capillary electrophoresis probes are comprised of one or more vinylogous carboxylic acid compounds or their derivative...
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WO/2001/037958A2 |
The present invention further provides a device for the micromanipulation, amplification, and analysis of polarized particles such as DNA. The device comprises a microchip (10) which contains constrictions (12) of insulating material for...
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WO/2001/031325A1 |
The invention concerns a method for separating a chemical or biological compound present in a mixture of similar compounds by diffusion in a gel containing a constituent (P) which reacts with the compounds of the mixture in reversible re...
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WO/2001/031315A1 |
The invention relates to methods and devices for particle separation, according to which, in a fluidic microsystem consisting of a particle mixture (1), target particles (2) with predetermined characteristics are separated from residual ...
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WO/2001/029098A2 |
A method for the manufacture of a separation gel, which comprises the steps: (i) providing a polymerisation mixture containing a first monomer (I) having a polymerisable unsaturated structure and a second monomer (II) comprising two or m...
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WO/2001/025491A1 |
This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the ...
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WO/2001/025490A1 |
This invention provides methods for removing unincorporated dye-labeled molecules from a mixture that includes dye-labeled polynucleotides or other polymers and the unincorporated dye-labeled molecules. The methods involve adsorbing the ...
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WO/2001/022078A1 |
The invention relates to a method for isolating and/or identifying at least one active chemical substance being contained in a mixture of active and inactive chemical substances. The inventive method is characterised by the steps: a) add...
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WO/2001/020315A1 |
An apparatus for rehydrating and for performing electrophoresis on a gel strip includes a tray defining a plurality of parallel troughs configured to receive gel strips. Each trough defines a centrally located rehydration area and an ele...
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WO2000028314A9 |
This invention relates to methods and formulations for the separation of biological macromolecules according to their size using capillary electrophoresis with improved polyacrylamide matrixes under denaturing conditions.
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WO/2001/017662A2 |
The present invention provides apparatuses and methods for continuously separating particles of interest from a heterogenous particle population. the heterogeneity can be based on, for example, magnetic susceptibility, particle size, the...
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WO/2001/014870A1 |
Methods and apparatus for discriminating matter in a chamber having an inlet port and an outlet port utilizing dielectrophoresis and field flow fractionation. A carrier medium is introduced into the inlet port and is directed from the in...
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WO/2001/014437A1 |
The instant invention describes uncharged water-soluble polymers to suppress electroosmotic flow in capillary electrophoresis. The polymers in the instant invention are copolymers of various derivatives of acrylamide and methacrylamide m...
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WO/2001/012327A1 |
A method for conducting a broad range of biochemical analyses or manipulations on a series of nano- to subnanoliter reaction volumes and an apparatus for carrying out the same are disclosed. The method and apparatus are implemented on a ...
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WO/2001/008802A1 |
An automated system utilizes an array of nanoscale capillary-dimension reaction chambers (12). The ends of the chambers are temporarily sealed with deformable membranes (264a, 264b) and the reactions effected by incubation or temperature...
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WO/2001/009389A2 |
Methods for preparing nanoscale reactions using nucleic acids are presented. Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is removed and...
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WO/2001/005512A1 |
In a dielectrophoretic cell having an array of electrodes and means to apply electrical signals to the electrodes, the electrodes comprise a planar array of serpentine or zig-zag electrodes with their curvatures in register. The serpenti...
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WO/2001/005513A1 |
In a method of manipulating particles suspended in a liquid medium, a moving standing wave ultrasonic vibration and an electrical field capable of generating a dielectrophoretic force on the particles are applied. The ultrasonic vibratio...
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WO/2001/005511A1 |
An electrode formation for use in an AC electrokinetic DEP or TWD or electrorotation cell comprises a substrate on which there is a set of conventional electrodes and a further electrode array to measure an AC electrokinetic-related prop...
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WO/2001/005514A1 |
A method of travelling wave dielectrophoresis applicable to a suspension of particles in which a first signal at a first frequency and a plurality of different phases is applied to generate a TWD force, and simultaneously a second signal...
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WO/2000/077163A1 |
An electrochemical device for moving particles covered with a protein, characterized in that it has at least n pieces (n ≥ 2) of electrodes contacting with a liquid containing particles covered with a protein and a circuit generating a...
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WO/2000/069565A1 |
The invention relates to an apparatus and a method for establishing closed dielectrophoretic potential cages and precise displacement thereof, suitable for the manipulation of particles and detection of same. The apparatus comprises a fi...
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WO/2000/067907A2 |
Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a...
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WO/2000/060065A1 |
An object of the invention is to provide a tangential flow, cell concentration and fusion apparatus (12) which includes a transparent housing (24) and a first input channel (1) contained in the housing (24). In the housing (24), a concen...
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WO/2000/056444A2 |
A composition of a liquid (26) is caused to interact with a narrow band shaped area at a chosen position on a solid surface within a flow channel (12) by hydrodynamic focusing of a guided stream of said liquid between two streams of guid...
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WO/2000/049173A2 |
This invention relates to a method and a device for separating substances into and from biological materials.
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WO/2000/046595A1 |
Microfluidic devices are provided where barriers are introduced between different compartments of the device to prevent fluid flow between the two compartments. Different materials and methods are employed for the introduction and remova...
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WO/2000/045147A2 |
The aim of the invention is to detect objects, especially in fluidic microsystems. At least one static or moving object (10) is represented on a structured mask (20) having at least one segment (30) which can transmit light from a planar...
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WO/2000/040958A1 |
The invention concerns a medium comprising an electrolyte wherein is dissolved at least an assembly of block copolymers characterised in that said block copolymers: are present in said electrolyte at a concentration level to provide said...
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WO/2000/038743A1 |
A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent...
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WO2000028315B1 |
A device for control of ultrasmall volume fluid flow used in the fields of electrophoretic separation, chemical analysis, and microchemical reactions has a substrate defining a capillary channel and integrated external electrodes to cont...
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WO/2000/038759A1 |
A method of treating blood or plasma of a subject to remove metabolic contaminants, the method comprising: (a) placing blood or plasma from the subject in a first solvent stream, the first solvent stream being separated from a second sol...
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WO/2000/037920A1 |
In order to effect dielectric spectroscopy on at least one suspended particle (11) in a microsystem, the particle (11) is exposed to high frequency electric rotating fields in an electrode array (16) and maintained in the focus (14) of a...
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WO/2000/037163A1 |
We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by stining the nuclei with fluorescent dye followed by lase...
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WO/2000/016907A1 |
A micromachined system for electrical field-flow fractionation of small test fluid samples is provided. The system includes a microchannel device (12) comprising a first substrate (14) having a planar inner surface with an electrode (21)...
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WO/2000/017631A1 |
The invention relates to a method and a system, suitable for automation, for the, preferably preparative, separation of amphoteric macromolecules, e.g. proteins or peptides, wherein said method comprises the steps of: (a) subjecting said...
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WO/2000/013776A1 |
An electrophoresis apparatus, holds a cartridge configured to be removably mounted in the apparatus. A separation membrane is located in the cartridge. The separation membrane has a first side along which a first flow path defined in a f...
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