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WO/2012/136682A1 |
The present invention is concerned with a method for differentiating in a subject infected with at least two high-risk (HR-) human papillomavirus (HPV) genotypes between a severe form of HPV infection and a mild form of HPV infection, co...
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WO/2012/139125A2 |
An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a continuous centrifugation emulsion breaking ...
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WO/2012/102367A1 |
Provided is a constant temperature device with reduced temperature differences inside the tank when a solution is being heat-treated. A stirring guide (114) for guiding water flow generated from a stirring bar (113) to the ends of a tank...
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WO/2012/093261A1 |
The present invention provides a method of operating a thermal cycler using readable tags (for example, Radio Frequency Identification (RFID)) to simplify the operation and to reduce user interaction requirements. The RFID tag is used to...
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WO/2012/080746A1 |
A microplate (100) for polymerase chain reaction (PCR) comprises a substrate (103) having a metallic material for heating PCR samples, and a barrier layer (104) disposed adjacent to the substrate. In some cases, the barrier layer is form...
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WO/2012/078930A2 |
A thermal cycler is provided. The thermal cycler comprises a tray assembly. The tray assembly comprises a main body made of a first material having a first thermal conductivity. The tray assembly further comprises an adaptor made of a se...
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WO/2012/073484A1 |
A thermal cycler (1) includes a holder (11) that holds a biotip (100) filled with a reaction mixture and liquid having a smaller specific gravity than the reaction mixture and being immiscible with the reaction mixture, the biotip (100) ...
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WO/2012/073114A2 |
Fabrication of a microfluidic multi-temperature reaction device (MMR) and the design and fabrication of the equipment to drive various molecular biological methods on the device are provided. The device can be applicable, for example, to...
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WO/2012/069463A2 |
The invention relates to a microfluidic system which consists of or comprises at least one substrate carrying electrodes (1), at least one fluidics part (20) having at least one microfluidic channel (30), at least one electrical resistan...
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WO/2012/066499A1 |
A flow-through apparatus comprising a reaction chamber having a temperature controlled surface adapted to provide a temperature controlled environment for a target analyte to react with test agents under controlled temperature conditions...
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WO/2012/063011A2 |
A vessel cup assembly for receiving a chemical and/or biological reaction process vessel containing reactants and processing the reaction therein and comprising: a reaction vessel receiving portion; a heater portion; and a cooling portio...
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WO/2012/049066A2 |
The present method is related to a method for identification and/or quantification of at least one polynucleotide target compound present in a biological sample among possible other ones by its amplification in a cycling flow chip soluti...
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WO/2012/037978A1 |
A method and device for performing direct quantitative real time PCR in a crude sample (200), wherein said sample is subjected to a centrifugal force sufficient to separate components of the sample into a supernatant and a pellet, and wh...
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WO/2012/038750A1 |
We describe a thermal cycler comprising a Peltier- type thermoelectric element (36) used for cooling a sample block (34), and a non- Peltier- type heating device (38) for heating the sample block. The cycler also includes a heat sink (28...
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WO/2012/033396A1 |
A polymerase chain reaction (PCR) device including a chip assembly, a plurality of chambers being provided in said chip assembly adapted to hold samples, heating means wherein said chip assembly being located on said heating means whereb...
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WO/2012/023722A2 |
Provided is a low heat capacity composite for a thermal cycler. The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducib...
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WO/2012/019119A1 |
Systems, devices and methods are described herein that are configured for use in the monitoring and detecting of chemical reactions, such as, for example, the monitoring and detection of Polymerase chain reactions (PCR). For example, the...
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WO/2011/153558A1 |
Disclosed is an apparatus and a method for reaction loading, in particular corrosion loading, at least one sample (1) comprising a housing (2) having a loading space (3), comprising a sample holder (4) for the sample (1) provided in the ...
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WO/2011/144345A1 |
The present invention provides a reaction vessel (20) for a PCR device. The reaction vessel (20) comprises a sample vial (32) defining a reaction chamber (33) for performing PCR and a storage vessel (62) defining a storage chamber (63) f...
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WO/2011/141132A1 |
The present invention relates to an apparatus for mixing and controlling the temperature of laboratory vessel contents with an accommodating device in detachable connection with an exchangeable block for accommodating and controlling the...
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WO/2011/138003A1 |
The invention relates to a device for controlling the temperature of laboratory vessels, comprising at least one vessel receptacle for receiving the laboratory vessels, at least one removably designed peripheral unit (31), and a base uni...
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WO/2011/138748A1 |
The invention provides a microfluidic chip support and a system for thermally regulating a specimen, enabling the temperature of a viscous or liquid specimen to be rapidly regulated in a spatially controlled and reproducible manner, whic...
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WO/2011/135111A1 |
The invention discloses a sample-support element for ultra-high vacuums comprising a main chamber and a supplementary chamber for the sample holder and the heating/cooling elements, which is pumped by a related pump line. This enables th...
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WO/2011/135535A1 |
The present disclosure provides a non contact real time micro Polymerase Chain Reaction [PCR] system comprises; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the...
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WO/2011/130785A1 |
A method of controlling the temperature of a liquid held within a reaction container in a chamber of a thermal cycling apparatus, the method including determining a sensed chamber temperature from a temperature sensor in the chamber, det...
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WO/2011/124918A1 |
A chemical and/or biochemical system (1) having at least one reaction vessel (3) in which chemical and/or biochemical reactions may take place, the temperature of the reaction vessels being cycled between at least a highest predetermined...
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WO/2011/124688A1 |
The invention relates to a device that allows a target nucleic acid to be detected in a homogeneous batch using two different detection formats. The device comprises at least two heatable sample blocks and a reaction cartridge which cont...
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WO/2011/117414A2 |
The invention relates to a device for carrying out PCR, comprising a sample holder (2) for holding sample vessels (3), wherein the sample holder (2) has a plurality of holder openings (21), in each of which a sample vessel or an insert (...
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WO/2011/108988A1 |
An improved low temperature testing equipment (1) for keeping biological samples and specimens, the low temperature testing equipment (1) comprising an insulated shell having a storage chamber (10) for keeping biological samples and spec...
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WO/2011/101635A1 |
A reaction vessel for conducting low temperature reactions is disclosed, the reaction vessel comprising: a circulation chamber with an entry port for the supply of a cooling medium at a temperature below ambient to said circulation chamb...
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WO/2011/066269A1 |
An automated, refrigerated specimen management system (ARSIMS) to hold sealed and/or opened sample/specimen tubes and/or containers that can be in the pre-analytical, in-process, or post-analytical phase of processing. The ARSIMS ensures...
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WO/2011/062471A2 |
The present invention provides a microfluidic device (100) comprises an adapting unit; a microvalve (120) adapted to removably couple with the adapting unit, the microvalve (120) having a fluid path (124) and a heat sensitive plug (126),...
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WO/2011/059443A1 |
The system can include a base plate adapted to rotate about a rotation axis. The system can further include a cover including a first projection, and a housing. A portion of the housing can be movable with respect to the base plate betwe...
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WO/2011/054353A1 |
The invention relates to a device (1) for performing a PCR method, wherein the device comprises at least one sample cell (5) having a cavity (8) for accommodating a sample and at least one first (2a), one second (2b), and one third (2c) ...
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WO/2011/047233A1 |
An apparatus for processing a liquid sample in a sample tube. The apparatus includes a base, a receptacle for receiving a sample tube, and a heating portion coupled to the base to selectively apply heat to the receptacle. A shaking porti...
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WO/2011/042426A1 |
A rotor capable of holding a plurality of vessels for subjecting samples to reactions involving thermal cycling in a thermal cycler, comprising a base element and an annular element for holding said plurality of vessels, wherein said ann...
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WO/2011/033231A1 |
The present invention relates to a disposable device (100) for amplifying at least one target nucleic acid present in a liquid biological sample of interest, which consists of a solid body (2), and of at least one fluidic channel (3) con...
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WO/2011/031377A1 |
Optical systems, and corresponding methods, for multiple reactions are provided. The optical systems are in a fixed position relative to a thermal assembly and include at least one array of excitation sources (e.g., light emitting diodes...
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WO/2011/023164A1 |
The invention relates to a device for cooling pathological/histological preparations, in particular in embedding cassettes of embedded pathological/histological samples, before they are cut by means of a microtome, comprising a cooled su...
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WO/2005/121864A9 |
An apparatus for imaging one or more selected fluorescence indications from a microfluidic device (205). The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device (205). The imaging path prov...
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WO/2011/008780A1 |
The present invention provides a device and method for heating a whole blood sample for use in an assay, comprising irradiating said whole blood sample with monochromatic visible light of between 380 nm and 740 nm to raise the temperatur...
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WO/2010/141131A1 |
Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The f...
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WO/2010/140982A1 |
There is disclosed a device for selectively maintaining a reactive sample at different temperatures during the course of a reaction, the device comprising: a body having a first part and a second part, at least one of the body parts bein...
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WO/2010/141139A1 |
Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to t...
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WO/2010/119396A1 |
The invention relates to real-time array PCR cartridges. The cartridge (100) has a fluid chamber (101) for a fluid bath (102) and a first support element (200) for fixing a microarray (103) in the fluid chamber (101). Thereby the first s...
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WO/2010/112273A1 |
The invention relates to a device for accommodating a biosensor, comprising a means for the electrical, fluidic, and thermal coupling of the biosensor, comprising a flap mechanism (26). In a closed state, the flap mechanism causes the bi...
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WO/2010/092137A2 |
The invention comprises a method for testing the accuracy and reliability of a thermal unit of a thermal cycler or an enclosure of a PCR thermal cycler thermally controlled by pulsed air, said thermal unit and enclosure thermally control...
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WO/2010/089470A1 |
The invention relates to a thermal validation apparatus (302) including at least one lining (316), each lining defining a sink (314) and intended to be inserted into a respective recess of the thermal processing device for heating or coo...
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WO/2010/088496A1 |
A signal detection system configured for detecting a signal emitted by the contents of a reaction receptacle is also configured to apply thermal energy to a portion of the reaction receptacle to affect a reaction occurring within the rea...
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WO/2010/084149A1 |
The invention relates to a plastic container or conduit for a cooling system, a heating system, an air intake system, an exhaust system, a pressure system or a fuel system, consisting of, or comprising a part or a layer made of a thermop...
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