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WO/2019/189422A1 |
A method for separating steviol glycoside(s), said method involving separation step 55 for performing continuous liquid chromatography wherein a liquid to be separated, which contains multiple kinds of steviol glycosides, is passed throu...
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WO/2019/186382A1 |
A system and a method for collecting waste in chromatography is provided. The system includes a base unit comprising a housing, wherein the housing comprises a plurality of openings, wherein the plurality of openings is configured to rec...
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WO/2019/190092A1 |
The present invention relates to a Bordetella pertussis-derived protein-obtaining method including an affinity chromatography process. The present invention increases the production yield of PT and FHA proteins by isolating PT and FHA pr...
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WO/2019/186579A1 |
Method of making a concentrate composition comprises heat stable proteins from juice of a plant part by subjecting the juice to heat treatment to precipitate heat precipitable/coagulable phytochemicals leaving behind Juice Solubles, and ...
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WO/2019/191133A1 |
Disclosed herein are methods of controlling, modulating, increasing, or improving protein yield in a sample mixture comprising a target protein and impurities comprising monitoring in real-time an ultraviolet (UV) signal of the sample mi...
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WO/2019/187377A1 |
This base material for a filler comprises a natural polymer immobilized on the surface of a porous organic polymer carrier, the porous organic polymer carrier has a crosslinking degree of 50-85 mol%, the exclusion limit molecular weight ...
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WO/2019/187603A1 |
A purpose of the present invention is to provide a peptide that has a high chemical stability to alkalis, etc. Another purpose of the present invention is to provide: a DNA encoding the aforesaid peptide; a vector containing the DNA; and...
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WO/2019/191192A1 |
A thermal pad for promoting heat transfer between a column heating module and a mobile phase of a liquid chromatography system includes is provided. The thermal pad includes a silicone layer, the silicone layer having a reinforcement sti...
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WO/2019/189064A1 |
In a method for producing a protein from animal cells, clogging of a column or filter closely packed in an airtight container makes continuous operation difficult. To solve this problem, provided is a module wherein: a slurry containing ...
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WO/2019/186469A1 |
The technology relates to a recycling chromatography method. A sampled is injected into a mobile phase flow stream of a liquid chromatography system creating a combined flow stream. The liquid chromatography system includes at least two ...
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WO/2019/187585A1 |
The purpose of the present invention is to provide a method for packing a carrier into a large column by supply of a slurry, wherein the method reliably produces a packed bed that makes it possible to reproducibly obtain a favorable chro...
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WO/2019/190046A1 |
The present invention relates to a method for concentrating a pathogen using diatoms and cucurbiturils. According to the present invention, a diatom-cucurbituril composite, which is prepared by modifying the surface of diatoms with a sil...
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WO/2019/189335A1 |
The present invention provides a device and method for performing treatment of a liquid such as a nucleic acid-containing sample liquid by a liquid-permeable carrier under stable conditions. This liquid passage device 1 is for passing a ...
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WO/2019/189807A1 |
The purpose of the present invention is to provide a method for packing a carrier into a large column by supply of a slurry, wherein the method reliably produces a packed bed that makes it possible to reproducibly obtain a favorable chro...
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WO/2019/178587A1 |
The present invention provides a method of purifying a target molecule in a sample containing the target molecule, for example, an acidic target molecule, that utilizes a multimodal ligand.
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WO/2019/178495A1 |
The present disclosure describes methods for purifying recombinant adenoassociated viruses (AAVs). Specifically, the methods involve separating AAV particles that include a nucleic acid payload (full AAV particles) and AAV particles that...
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WO/2019/175849A1 |
The present disclosure concerns the development of a novel stationary phase for the separation of nucleic acids in the context of preparative chromatography, using a chromatographic matrix, preferably a macroporous matrix, particularly a...
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WO/2019/172836A1 |
A protein-binding product comprising one or more porous polymer beads, wherein at least one ligand is bound to the surfaces of said polymer beads via a spacer (R), and wherein said at least one ligand is Galβ1-3Hex NAcβ-O-, Galβ1-4Glc...
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WO/2019/173731A1 |
Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatograp...
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WO/2019/170635A1 |
The present invention relates to composite materials useful for purifying proteins obtained from biological feedstocks. The composite materials of the invention comprise a porous support having an average pore size of 5 to 500 nm, said p...
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WO/2019/171625A1 |
The present invention is an apparatus for connecting a supercritical fluid extraction device and a liquid chromatograph mass spectrometer, the apparatus being provided with a dilution part, a six-port valve, and a trap column, the diluti...
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WO/2019/170634A1 |
The present invention relates to composite materials useful for purifying proteins obtained from biological feedstocks. The composite materials of the invention comprise a porous support having an average pore size of 5 to 500 nm, said p...
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WO/2019/171004A1 |
The invention relates to a method for chromatographic purification of an initial flow containing ammonium sulphate and 2-hydroxy-2-methylpropionic acid, comprising: - passing the initial flow over a stationary phase bed; - eluting a refi...
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WO/2019/167011A1 |
The invention relates to a liquid chromatography fluid supply device (150) for providing a mixture of several different fluids as a mobile phase for a liquid chromatography sample separation device (10), wherein the fluid supply device (...
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WO/2019/169040A1 |
Provided herein are compositions, methods and uses that relate to or result from providing separation media having at least one flocculant ligand covalently attached to a base surface or support, and the separation and/or purification of...
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WO/2019/168114A1 |
This chromatographic separation method employs chromatography to separate a plurality of components, contained in a liquid to be separated, by means of a chromatographic separation device 1 provided with a plurality of filling portions 1...
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WO/2019/167441A1 |
Provided is a toxin separator or the like that is to be used for a toxin bound to a protein and present in an organism-derived liquid and that is capable of selectively separating the toxin from between the toxin and the protein. The tox...
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WO/2019/169303A1 |
The disclosure features methods that include obtaining a vibrational spectrum (804) of a solution in a biological manufacturing system, analyzing the vibrational spectrum (806) using a first chemometrics model to determine a value of a f...
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WO/2019/168508A1 |
The method and materials of this invention make possible substantially faster techniques for organic-aqueous extractions and routine chemical reactions work- ups. The inventive material uses silicone elastomer-coated glass powders, magne...
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WO/2019/164918A1 |
A pump for high-pressure and/or nano-scale volumes permits identification of the internal pressure of the pump.
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WO/2019/164227A1 |
The present invention relates to a multi-column for isolating exosomes and an exosome isolation method, for isolating exosomes from a biological sample containing exosomes mixed with impurities such as lipoproteins and water-soluble prot...
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WO/2019/165148A1 |
Technologies are described related to determining conditions for the purification of proteins. In some implementations, models can be generated that predict yield and purity for various chromatographic techniques at a number of pH levels...
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WO/2019/163499A1 |
Provided is a method for producing a chelate resin, wherein a highly pure treatment liquid can be obtained by reducing the amount of metal impurities in a to-be-treated liquid containing metal impurities. The method for producing a chela...
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WO/2019/163245A1 |
This quinone analysis method comprises: a sample sealing step for sealing a sample including quinones in an extraction container; an extraction step for, after the sample sealing step and as a series of extraction operations, carrying ou...
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WO/2019/161252A1 |
Chromatographic processes are provided which utilize fiber conduit contactors to effect separation of chemical substances from a mixture. In particular, processes are provided which constrain a substance on the fibers and move a mixture ...
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WO/2019/160640A1 |
A method of purifying a rendered fat by contacting the rendered fat with at least one adsorbent material, such as magnesium silicate. The at least one adsorbent material may be used alone or in combination with other purifying materials,...
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WO/2019/155411A1 |
The invention relates to a method of purifying and/or separating lipopeptide surfactants of the natural origin using the Countercurrent Chromatography (CCC) characterised in that: the purification occurs within the system of two partiall...
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WO/2019/150137A1 |
This invention relates to a method of removing a chemical entity from a liquid using affinity chromatography. The method involves passing an elongate solid phase through a conduit through which the liquid also flows.
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WO/2019/152970A1 |
A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic ...
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WO/2019/152352A1 |
Methods for achieving complete sequence coverage of monoclonal antibodies by trypsin digestion and dual-column LC-MS system are provided. The disclosed method improves upon current techniques for standard peptide mapping.
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WO/2019/152411A1 |
A method for producing an ethanol product includes obtaining a condensed distillate including ethanol at a concentration greater than 30% by volume and contacting the condensed distillate with an adsorbent polymer resin. The adsorbent po...
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WO/2019/149878A1 |
The present invention relates to ligand that may be a peptide compound as well as peptoid or retro- inverso analogues thereof with binding affinity for the Fc region of immunoglobulins. The invention further relates to the application of...
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WO/2019/145117A1 |
The invention relates to a method for determining impurities in polyalkylene ethers or polyalkylene amines, comprising the following steps: i) introducing polyalkylene ethers or polyalkylene amines as the analyte into a chromatography co...
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WO/2019/145920A1 |
The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. T...
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WO/2019/147555A1 |
Disclosed is a method for the enrichment and purification of circulating, cell-free DNA (cfDNA) from a biological specimen. The method uses optimized mixtures and ratios of magnetic particles and reagents to efficiently enrich, purify, a...
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WO/2019/144228A1 |
The valve assembly (100) includes a main valve body (102) defining a first inner cylindrical cavity (180), a support plate (170) positioned above the main valve body (102), and an upper valve head (104) positioned above the support plate...
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WO/2019/145552A1 |
The present specification discloses methods of purifying one or more cannabinoids from a plant material using unique biphasic solvent systems and liquid-liquid chromatography as centrifugation partitioning chromatography (CPC) or counter...
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WO/2019/142034A1 |
Exemplary embodiments are directed to methods and systems for managing fluid decompression. A fluid connector (703) is located downstream of a chromatography column and defines an interior bore (705) through which a fluid can pass. The i...
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WO/2019/143251A2 |
Continuous process in which a subset of a number of mutually identical columns, are connected in series. The process liquid, e.g. crude cell culture harvest, is supplied to the most upstream column of the subset, flows successively throu...
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WO/2019/138338A1 |
The present patent application discloses a new and innovative method for purification of glycerol derivatives, by simulated moving bed chromatography. The method of the present patent application allows the separation of at least one gly...
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