Title:
VITAMIN D3-LIKE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/270443
Kind Code:
A1
Abstract:
Provided is a novel vitamin D3-like compound. A compound according to the present invention is represented by formula (1). In the formula, m and n are independently 0 or 1, p is an integer of 0-4, and s is an integer of 0-4. Y represents an oxygen atom, a sulfur atom, or a divalent group represented by -NR6-. R1 represents a predetermined monovalent aliphatic hydrocarbon group. R2 represents a predetermined alkyl group, a hydroxyl group, a predetermined alkoxy group, or a halogen atom. R3 represents a predetermined divalent aliphatic hydrocarbon group which may have a substituent and may contain a heteroatom in a carbon chain. R4 represents a predetermined monovalent aliphatic hydrocarbon group. R5 represents a hydrogen atom, a hydroxyl group, a predetermined alkoxy group which may have a substituent, or a predetermined monovalent aliphatic hydrocarbon group which may have a substituent. R6 represents a hydrogen atom or a monovalent aliphatic hydrocarbon group. R7 and R8 both represent a hydrogen atom, or are integrated to represent a methylidene group.
Inventors:
OKAMOTO SENTARO (JP)
IBE KOTA (JP)
IBE KOTA (JP)
Application Number:
PCT/JP2022/024408
Publication Date:
December 29, 2022
Filing Date:
June 17, 2022
Export Citation:
Assignee:
UNIV KANAGAWA (JP)
International Classes:
C07C29/132; C07C33/38; C07C39/23; C07C41/18
Domestic Patent References:
| WO2002066424A1 | 2002-08-29 |
Foreign References:
| JP2006514673A | 2006-05-11 | |||
| JP2005511731A | 2005-04-28 | |||
| JP2002505668A | 2002-02-19 | |||
| US20210032194A1 | 2021-02-04 |
Other References:
MIGUEL A. MAESTRO, FERDINAND MOLNáR, CARSTEN CARLBERG: "Vitamin D and Its Synthetic Analogs", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 62, no. 15, 8 August 2019 (2019-08-08), US , pages 6854 - 6875, XP055702171, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b00208
BOUILLON R, ET AL.: "Structure function analysis of vitamin D analogs with C-ring modifications", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 267, no. 5, 15 February 1992 (1992-02-15), US , pages 3044 - 3051, XP003001259, ISSN: 0021-9258
GAO ANG, LIU XIU-YAN, DING CHANG-HUA, HOU XUE-LONG: "Diastereoselective Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to α-Substituted Cyclic Enones", SYNLETT, GEORG THIEME VERLAG, DE, vol. 28, no. 20, 1 December 2017 (2017-12-01), DE , pages 2829 - 2832, XP093016417, ISSN: 0936-5214, DOI: 10.1055/s-0036-1590742
BOUILLON R, ET AL.: "Structure function analysis of vitamin D analogs with C-ring modifications", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 267, no. 5, 15 February 1992 (1992-02-15), US , pages 3044 - 3051, XP003001259, ISSN: 0021-9258
GAO ANG, LIU XIU-YAN, DING CHANG-HUA, HOU XUE-LONG: "Diastereoselective Palladium-Catalyzed Conjugate Addition of Arylboronic Acids to α-Substituted Cyclic Enones", SYNLETT, GEORG THIEME VERLAG, DE, vol. 28, no. 20, 1 December 2017 (2017-12-01), DE , pages 2829 - 2832, XP093016417, ISSN: 0936-5214, DOI: 10.1055/s-0036-1590742
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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