Title:
VITAMIN D3-LIKE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/269768
Kind Code:
A1
Abstract:
Provided is a novel vitamin D3-like compound. The compound according to the present invention is represented by formula (1). In the formula, m and n independently represent 0 or 1; p represents an integer of 0 to 4; s represents an integer of 0 to 4; Y represents an oxygen atom, a sulfur atom, or a bivalent group represented by -NR6-; R1 represents a specific monovalent aliphatic hydrocarbon group; R2 represents a specific alkyl group, a hydroxyl group, a specific alkoxy group, or a halogen atom; R3 represents a specific bivalent aliphatic hydrocarbon group which may have a substituent and may contain a hetero atom in a carbon chain thereof; R4 represents a specific monovalent aliphatic hydrocarbon group; R5 represents a hydrogen atom, a hydroxyl group, a specific alkoxy group which may have a substituent, or a specific monovalent aliphatic hydrocarbon group which may have a substituent; R6 represents a hydrogen atom or a monovalent aliphatic hydrocarbon group; and R7 and R8 respectively represent hydrogen atoms concurrently or together form a methylidene group.
Inventors:
OKAMOTO SENTARO (JP)
IBE KOUTA (JP)
IBE KOUTA (JP)
Application Number:
PCT/JP2021/023645
Publication Date:
December 29, 2022
Filing Date:
June 22, 2021
Export Citation:
Assignee:
UNIV KANAGAWA (JP)
International Classes:
C07C29/132; C07C33/38; C07C39/23; C07C41/18; C07C43/23
Domestic Patent References:
| WO2002066424A1 | 2002-08-29 |
Foreign References:
| JP2006514673A | 2006-05-11 | |||
| JP2005511731A | 2005-04-28 | |||
| JP2002505668A | 2002-02-19 | |||
| US20210032194A1 | 2021-02-04 |
Other References:
MAESTRO, M. A. ET AL.: "Vitamin D and its synthetic analogs", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 2019, pages 6854 - 6875, XP055702171, DOI: 10.1021/acs.jmedchem.9b00208
BOUILLON, R. ET AL.: "Structure function analysis of vitamin D analogs with C-ring modifications", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 5, 1992, pages 3044 - 3051, XP003001259, DOI: 10.1016/S0021- 9258 (19) 50692-5
BOUILLON, R. ET AL.: "Structure function analysis of vitamin D analogs with C-ring modifications", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 5, 1992, pages 3044 - 3051, XP003001259, DOI: 10.1016/S0021- 9258 (19) 50692-5
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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