VITAMIN C-ENCAPSULATED LIPOSOME AND PREPARATION METHOD THEREFOR

WIPO Patent Application WO/2024/048815

A1

The present invention provides a method for preparing vitamin C-encapsulated liposomes, an oral liposome composition prepared according thereto, and an application method thereof, wherein the preparing method comprises the steps of: (i) mixing in an aqueous solution 10-30 wt% lecithin, 10-30 wt% vitamin C, and 1-10 wt% citric acid; (ii) homogenizing the mixture at a temperature of 60-70°C for 10-30 minutes at 5,000-7,000 rpm; (iii) stirring the homogenate at a temperature of 60-70°C for 60-120 minutes at 30-90 rpm; and (iv) cooling the stirred mixture.

KIM ANDRE (KR)
HA JONG-MYUNG (KR)
CHA JAE YOUNG (KR)
LEE KEUN WOO (KR)
WOO YOUNG MIN (KR)
JO EUN SOL (KR)

PCT/KR2022/013061

March 07, 2024

August 31, 2022

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HANKOOK LIPOSOME CO LTD (KR)

A61K9/127; A23L33/15; A23P10/30; A61K31/375; A61K47/12; A61K47/24

KR20160149398A	2016-12-28
KR20220051970A	2022-04-27
US20140141066A1	2014-05-22
KR20020008598A	2002-01-31

KIM, KWON BUM: " Studies on Processing Condition Optimization and Storage Stability of Encapsulated Vitamin C and Aronia Concentrate by Liposome", THESIS, THE GRADUATE SCHOOL OF KONKUK UNIVERSITY., 31 August 2014 (2014-08-31), XP093144205, [retrieved on 20240321]
JI HYUN CHA, YOUNG MIN WOO, EUN SOL JO, JAE YOUNG CHA, SANG HYEON LEE, KEUN WOO LEE, ANDRE KIM: " Development of a method for producing liposome ascorbic acid with increased bio-absorption.", JOURNAL OF LIFE SCIENCE, KOREAN SOCIETY OF LIFE SCIENCE, KR, vol. 32, no. 3, 30 March 2022 (2022-03-30), KR , pages 232 - 240, XP093144193, ISSN: 1225-9918, DOI: 10.5352/JLS.2022.32.3.232

BAEK, Seoil (KR)

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