Title:
USP INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2023/208151
Kind Code:
A1
Abstract:
The present disclosure provides a compound which has an inhibitory effect on USP, a pharmaceutically acceptable salt, a stereoisomer, a solvate or a prodrug thereof, as shown in formula (I), the definition of each group in the formula being detailed in the description. In addition, the present disclosure further provides a preparation method for the compound, a pharmaceutical composition including the compound, a use thereof in preparing a USP inhibitor, preparing a drug for treating cardiovascular diseases, neurological disorders, cancers or immune diseases, or preparing a kit for cardiovascular disease, neurological disorder, cancer, immune disease or patient prognosis evaluation, a method for inhibiting USP activity in a biological sample, and a method for treating USP21-mediated diseases, cardiovascular diseases, neurological disorders, cancers or immune diseases.
Inventors:
LIU XIAOHUI (CN)
WANG YUXUN (CN)
ZHANG WEI (CN)
WANG YUXUN (CN)
ZHANG WEI (CN)
Application Number:
PCT/CN2023/091368
Publication Date:
November 02, 2023
Filing Date:
April 27, 2023
Export Citation:
Assignee:
BEIJING PHARSCIN INNOBIO CO LTD (CN)
International Classes:
A61K31/395; A61K31/435; A61P35/00; C07C23/18; C07D221/06; C07D221/16; C07D239/00
Foreign References:
| CN104513147A | 2015-04-15 | |||
| US20170088520A1 | 2017-03-30 | |||
| CN104471022A | 2015-03-25 | |||
| CN109320426A | 2019-02-12 | |||
| GB1314899A | 1973-04-26 | |||
| JPS6071635A | 1985-04-23 | |||
| KR20160017241A | 2016-02-16 | |||
| US3491145A | 1970-01-20 |
Other References:
WEI, ZHANG; SACHDEV S. SIDHU: "Development of Inhibitors in the Ubiquitination Cascade", FEBS LETTERS, vol. 588, no. 2, 12 November 2013 (2013-11-12), XP028669977, ISSN: 0014-5793, DOI: 10.1016/j.febslet.2013.11.003
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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