Title:
USE OF TROPIC ACID AND DERIVATIVE THEREOF IN PREPARATION OF DRUG FOR TREATING PSORIASIS
Document Type and Number:
WIPO Patent Application WO/2024/088153
Kind Code:
A1
Abstract:
The use of tropic acid and a derivative thereof in the preparation of a drug for treating psoriasis. It is found that tropic acid and the derivative thereof can significantly improve skin damage of a psoriasis animal model. The tropic acid and the derivative thereof have low toxicity, fast action, a short treatment course, a small dosage, a low recurrence rate and is convenient to use, and the dosage forms for external use, oral administration, injection, etc. are taken into consideration, such that it is possible to adapt to patients with different degrees and different types of psoriasis. It is also found that compounds III and IV obtained by means of structural modification have a significantly better therapeutic effect than tropic acid. The small molecule drugs used are easily obtained, have a low price and stable properties, are convenient to store and transport, and have broad application prospects.
Inventors:
WANG CHANGFU (CN)
XIE RUIQIANG (CN)
XIN PING (CN)
XIE RUIQIANG (CN)
XIN PING (CN)
Application Number:
PCT/CN2023/125517
Publication Date:
May 02, 2024
Filing Date:
October 20, 2023
Export Citation:
Assignee:
UNIV GUANGDONG PHARM (CN)
International Classes:
A61K31/192; A61P17/06; C07C59/52
Foreign References:
| CN115869294A | 2023-03-31 | |||
| CN116440110A | 2023-07-18 | |||
| US5637615A | 1997-06-10 | |||
| US5877212A | 1999-03-02 | |||
| US5665776A | 1997-09-09 | |||
| US4363815A | 1982-12-14 | |||
| US5389677A | 1995-02-14 |
Other References:
LI ， ZHEN-YU: "Study on Chemical Constituents from the Datura Metel L. (Ⅳ)", INFORMATION ON TRADITIONAL CHINESE MEDICINE, vol. 27, no. 6, 10 November 2010 (2010-11-10), pages 13 - 14, XP093162593, DOI: 10.19656/j.cnki.1002-2406.2010.06.007
YANG BINGYOU: "Study on Chemical Constituents of Datura Metel L (I)", CHINESE TRADITIONAL AND HERBAL DRUGS, TAINJIN ZHONGCAOYAO ZAZAHISHE, CN, vol. 37, no. 8, 12 August 2006 (2006-08-12), CN , pages 1147 - 1149, XP093162598, ISSN: 0253-2670, DOI: 10.3321/j.issn:0253-2670.2006.08.010
YANG BINGYOU: "Study on Chemical Constituents of Datura Metel L (III)", CHINESE JOURNAL OF TRADITIONAL MEDICAL SCIENCE AND TECHNOLOGY, vol. 13, no. 4, 20 July 2006 (2006-07-20), pages 253 - 254, XP093162602
YANG BINGYOU: "Study on Chemical Constituents of Datura Metel L (I)", CHINESE TRADITIONAL AND HERBAL DRUGS, TAINJIN ZHONGCAOYAO ZAZAHISHE, CN, vol. 37, no. 8, 12 August 2006 (2006-08-12), CN , pages 1147 - 1149, XP093162598, ISSN: 0253-2670, DOI: 10.3321/j.issn:0253-2670.2006.08.010
YANG BINGYOU: "Study on Chemical Constituents of Datura Metel L (III)", CHINESE JOURNAL OF TRADITIONAL MEDICAL SCIENCE AND TECHNOLOGY, vol. 13, no. 4, 20 July 2006 (2006-07-20), pages 253 - 254, XP093162602
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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