Title:
USE OF MESENCHYMAL STEM CELL
Document Type and Number:
WIPO Patent Application WO/2024/092508
Kind Code:
A1
Abstract:
Provided are a method of a mesenchymal stem cell, e.g., a placenta-derived mesenchymal stem cell, for enhancing the treatment of a tumor by a CAR-T cell and/or treating a tumor in combination with a CAR-T cell, corresponding use, and a corresponding composition. The mesenchymal stem cell enhances the proliferation ability and persistence of a CAR-T cell in vivo, and regulates and controls the differentiation of the CAR-T cell, so as to allow the CAR-T cell to be in a low-differentiation state and increase the differentiation of the CAR-T cell into a memory cell subtype.
Inventors:
ZHONG XIAOSONG (CN)
GU AIQIN (CN)
GU AIQIN (CN)
Application Number:
PCT/CN2022/128989
Publication Date:
May 10, 2024
Filing Date:
November 01, 2022
Export Citation:
Assignee:
CARRIAGE PHARMACEUTIC BEIJING CO LTD (CN)
International Classes:
C12N5/0775; A61K35/28; A61K39/00; A61P35/00; A61P35/02
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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