Title:
USE OF IMIDAZOLIDINYL VANILLIC ACID ETHER DERIVATIVE IN TREATMENT OF DISEASE ACCOMPANIED BY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2024/074116
Kind Code:
A1
Abstract:
The present invention relates to use of a compound represented by formula (I) or an ester thereof or a pharmaceutically acceptable salt thereof in the treatment of a disease accompanied by fibrosis.
Inventors:
CHU ZHAOXING (CN)
MO JIAJIA (CN)
ZHAO YAN (CN)
LIN GAOFENG (CN)
SHAO LI (CN)
XU QINLONG (CN)
HE GUANGWEI (CN)
MO JIAJIA (CN)
ZHAO YAN (CN)
LIN GAOFENG (CN)
SHAO LI (CN)
XU QINLONG (CN)
HE GUANGWEI (CN)
Application Number:
PCT/CN2023/122562
Publication Date:
April 11, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
HEFEI INST OF PHARMACEUTICAL INDUSTRY CO LTD (CN)
HEFEI AMVITE PHARMACEUTICAL CO LTD (CN)
HEFEI AMVITE PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4164; A61P1/16; A61P9/00; A61P11/00; A61P13/08; A61P13/10; A61P17/00; A61P37/02
Foreign References:
| CN114736161A | 2022-07-12 | |||
| CN101851209A | 2010-10-06 |
Other References:
ZHANG ENLI, ZHOU PENG, LI JIAMING, HE YONG, YUAN MING, XU QINLONG: "Synthesis of 4-[2-hydroxy-3-(1H-imidazolyl-1)propoxy]-3-methoxybenzoic acid and its analogues", SHANGHAI HUAGONG - SHANGHAI CHEMICAL INDUSTRY, SHANGHAI, CN, vol. 37, no. 9, 30 September 2012 (2012-09-30), CN , pages 14 - 16, XP009551337, ISSN: 1004-017X, DOI: 10.16759/j.cnki.issn.1004-017x.2012.09.012
ZHOU PENG, HE YONG, LI JIAMING, XU QINLONG, SHENG RIZHENG: "Synthesis of Imidazole-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 28, no. 5, 31 May 2011 (2011-05-31), CN , pages 446 - 450, XP009551336, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2011.05.025
JINRU HUANG: "The neuroprotective effect of a novel agent N2 on rat cerebral ischemia associated with the activation of PI3K/Akt signaling pathway", NEUROPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 95, 1 August 2015 (2015-08-01), AMSTERDAM, NL, pages 12 - 21, XP093157360, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2015.02.022
LIJIAN YANG: "N2 extenuates experimental ischemic stroke through platelet aggregation inhibition", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 136, no. 6, 1 December 2015 (2015-12-01), AMSTERDAM, NL , pages 1310 - 1317, XP093157361, ISSN: 0049-3848, DOI: 10.1016/j.thromres.2015.10.039
ZHOU PENG, HE YONG, LI JIAMING, XU QINLONG, SHENG RIZHENG: "Synthesis of Imidazole-Aromatic Acid Derivatives and Their Inhibitory Effect on Platelet Aggregation", CHINESE JOURNAL OF MODERN APPLIED PHARMACY, CHINESE PHARMACEUTICAL ASSOCIATION, CN, vol. 28, no. 5, 31 May 2011 (2011-05-31), CN , pages 446 - 450, XP009551336, ISSN: 1007-7693, DOI: 10.13748/j.cnki.issn1007-7693.2011.05.025
JINRU HUANG: "The neuroprotective effect of a novel agent N2 on rat cerebral ischemia associated with the activation of PI3K/Akt signaling pathway", NEUROPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 95, 1 August 2015 (2015-08-01), AMSTERDAM, NL, pages 12 - 21, XP093157360, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2015.02.022
LIJIAN YANG: "N2 extenuates experimental ischemic stroke through platelet aggregation inhibition", THROMBOSIS RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 136, no. 6, 1 December 2015 (2015-12-01), AMSTERDAM, NL , pages 1310 - 1317, XP093157361, ISSN: 0049-3848, DOI: 10.1016/j.thromres.2015.10.039
Attorney, Agent or Firm:
JINGTIAN & GONGCHENG (CN)
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