Title:
USE OF AKR1C3 INHIBITOR IN PREPARATION OF DRUG FOR TREATING OR PREVENTING METABOLIC ASSOCIATED FATTY LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/067891
Kind Code:
A2
Abstract:
Disclosed in the present application are the use of an Aldo-Keto reductase family 1 member C3 (AKR1C3) inhibitor in the inhibition of lipid droplet generation and the promotion of lipid droplet degradation and in the preparation of a drug for treating or preventing MAFLD, a pharmaceutical composition containing the inhibitor, the use of the inhibitor as a drug for treating diseases associated with an abnormal increase in lipid droplets, a method for inhibiting Aldo-Keto reductase family 1 member C3 (AKR1C3), a method for constructing a gene engineering animal model with MAFLD, etc.
Inventors:
LIU YANG (CN)
SUN SIYU (CN)
SUN SIYU (CN)
Application Number:
PCT/CN2023/133963
Publication Date:
April 04, 2024
Filing Date:
November 24, 2023
Export Citation:
Assignee:
SHENGJING HOSPITAL CHINA MEDICAL UNIV (CN)
International Classes:
A61K45/00; A01K67/02; A61K48/00; A61P1/16; A61P3/00; A61P3/06
Attorney, Agent or Firm:
BEIJING TANGSONG IP FIRM (CN)
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