Title:
UNIVERSAL IMMUNE EFFECTOR CELL, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027758
Kind Code:
A1
Abstract:
The present invention provides a universal immune effector cell, and in particular a universal CAR-T cell (IRU-CAR-T), a preparation method therefor, and use thereof. The universal CAR-T cell introduces a CAR and a mutated CnA or CnB fragment by using a gene editing technology. The combination use of the universal CAR-T cell of the present invention and an immunosuppressive drug to treat tumors can reduce the activity of T cells of a patient, thereby reducing the rejection reaction of the patient on the IRU-CAR-T cell, improving the colonization of the IRU-CAR-T cell in the patient and exerting the anti-cancer effect thereof. The universal immune effector cell of the present invention makes the strategy of withdrawal after use of the CAR-T possible, and can greatly improve the security of CAR-T therapy.
Inventors:
ZENG XUN (CN)
FANG HONGYU (CN)
ZHANG YIXI (CN)
WANG GUOCAN (CN)
FANG HONGYU (CN)
ZHANG YIXI (CN)
WANG GUOCAN (CN)
Application Number:
PCT/CN2023/110736
Publication Date:
February 08, 2024
Filing Date:
August 02, 2023
Export Citation:
Assignee:
THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE (CN)
International Classes:
C12N5/0783; A61P35/00; A61P37/06; C07K14/725; C12N5/10
Domestic Patent References:
| WO2021205173A1 | 2021-10-14 |
Foreign References:
| CN105765061A | 2016-07-13 | |||
| CN106103490A | 2016-11-09 | |||
| CN112839671A | 2021-05-25 | |||
| CN1691960A | 2005-11-02 |
Attorney, Agent or Firm:
BEIJING YUNJIN IP LAW FIRM (CN)
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