Title:
TRICYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/020416
Kind Code:
A1
Abstract:
A tricyclic compound of formula (I), a pharmaceutical composition comprising same, and use thereof as an HDAC6 inhibitor.
Inventors:
LI JIAPENG (CN)
WANG KUIFENG (CN)
WANG KUIFENG (CN)
Application Number:
PCT/CN2022/112425
Publication Date:
February 23, 2023
Filing Date:
August 15, 2022
Export Citation:
Assignee:
SUZHOU GENHOUSE BIO CO LTD (CN)
International Classes:
C07D243/38; A61K31/551; A61P9/00; A61P25/00; A61P31/00; A61P35/00; A61P37/00; C07D471/04
Domestic Patent References:
| WO2009137462A2 | 2009-11-12 |
Foreign References:
| CN101573333A | 2009-11-04 | |||
| CN101142197A | 2008-03-12 | |||
| CN1507441A | 2004-06-23 |
Other References:
ZHAO WEN-NING, GHOSH BALARAM, TYLER MARSHALL, LALONDE JASMIN, JOSEPH NADINE F., KOSARIC NINA, FASS DANIEL M., TSAI LI-HUEI, MAZITS: "Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory", ACS CHEMICAL NEUROSCIENCE, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 9, 19 September 2018 (2018-09-19), US , pages 2262 - 2273, XP093037334, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00116
ROB DE VREESE; LISA GALLE; YVES DEPETTER; JORICK FRANCEUS; TOM DESMET; KRISTOF VAN HECKE; VERONICK BENOY; LUDO VAN DEN BOSCH; MATT: "Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane‐ or Cycloheptane‐Annulated 1,5‐Benzothiazepine Scaffold", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 1, 30 November 2016 (2016-11-30), DE, pages 128 - 136, XP071842681, ISSN: 0947-6539, DOI: 10.1002/chem.201604167
VREESE ROB DE, KOCK CARMEN DE, SMITH PETER J, CHIBALE KELLY, D'HOOGHE MATTHIAS: "Exploration of thiaheterocyclic h HDAC6 inhibitors as potential antiplasmodial agents", FUTURE MEDICINAL CHEMISTRY, FUTURE SCIENCE LTD., GB, vol. 9, no. 4, 1 March 2017 (2017-03-01), GB , pages 357 - 364, XP093037332, ISSN: 1756-8919, DOI: 10.4155/fmc-2016-0215
ROB DE VREESE; LISA GALLE; YVES DEPETTER; JORICK FRANCEUS; TOM DESMET; KRISTOF VAN HECKE; VERONICK BENOY; LUDO VAN DEN BOSCH; MATT: "Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane‐ or Cycloheptane‐Annulated 1,5‐Benzothiazepine Scaffold", CHEMISTRY - A EUROPEAN JOURNAL, JOHN WILEY & SONS, INC, DE, vol. 23, no. 1, 30 November 2016 (2016-11-30), DE, pages 128 - 136, XP071842681, ISSN: 0947-6539, DOI: 10.1002/chem.201604167
VREESE ROB DE, KOCK CARMEN DE, SMITH PETER J, CHIBALE KELLY, D'HOOGHE MATTHIAS: "Exploration of thiaheterocyclic h HDAC6 inhibitors as potential antiplasmodial agents", FUTURE MEDICINAL CHEMISTRY, FUTURE SCIENCE LTD., GB, vol. 9, no. 4, 1 March 2017 (2017-03-01), GB , pages 357 - 364, XP093037332, ISSN: 1756-8919, DOI: 10.4155/fmc-2016-0215
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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