Title:
TRIAZINE COMPOUND SALT, CRYSTAL FORM THEREOF, AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/059700
Kind Code:
A1
Abstract:
The present invention provides a triazine compound salt that has an aldosterone synthase inhibitory effect and is useful as a medicine, in particular, an agent for preventing or treating primary aldosteronism and the like, a crystal, and a production method therefor. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoyl methyl]piperazine-1-yl]-5-(p-tolyl)-1,2,4-triazine, the salt being a hydrobromide, a sulfate, a succinate, or a tosilate.
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Inventors:
YAMAGAMI TAKAFUMI (JP)
SETSUTA TOMOFUMI (JP)
SUGIURA YOSHIHIRO (JP)
UEDA NAOKO (JP)
SETSUTA TOMOFUMI (JP)
SUGIURA YOSHIHIRO (JP)
UEDA NAOKO (JP)
Application Number:
PCT/JP2021/033901
Publication Date:
March 24, 2022
Filing Date:
September 15, 2021
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
A61P1/16; A61K31/53; A61P3/00; A61P3/04; A61P5/38; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P25/00; A61P27/02; A61P43/00; C07D253/07; C07D295/15; C07D295/205
Domestic Patent References:
| WO2015163427A1 | 2015-10-29 | |||
| WO2017069226A1 | 2017-04-27 | |||
| WO2010092962A1 | 2010-08-19 | |||
| WO1999064051A1 | 1999-12-16 | |||
| WO2015163427A1 | 2015-10-29 |
Foreign References:
| JP2017081911A | 2017-05-18 | |||
| JP2016526563A | 2016-09-05 | |||
| JP2013512903A | 2013-04-18 | |||
| JP2012533553A | 2012-12-27 | |||
| JP2010502668A | 2010-01-28 |
Other References:
DATABASE REGISTRY 27 January 2015 (2015-01-27), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -1643919-88-3 REGISTRY ED -Entered STN: 27 Jan 2015 CN -2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino[[trans-4-[[2-(4- methyl-1-piperazinyl)acetyl]amino]cyclohexyl]amino]methyl]- (CA INDEX NAME)", XP055912420, retrieved from STN Database accession no. 1643919-88-3
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY SONS, INC.
CHABRE ET AL., JCE M, vol. 85, no. 11, 2000, pages 4060 - 68
THEODORA W. GREENEPETER G.M. WUTS: "Protective Groups in Organic Synthesis", 2007, JOHN WILEY SONS, INC.
CHABRE ET AL., JCE M, vol. 85, no. 11, 2000, pages 4060 - 68
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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