Title:
TREATMENT OF GEOGRAPHIC ATROPHY
Document Type and Number:
WIPO Patent Application WO/2024/073097
Kind Code:
A3
Abstract:
Methods and compositions for treatment of geographic atrophy are described. A method of treating a subject suffering from or at risk of geographic atrophy (GA), e.g., GA secondary to age related macular degeneration (AMD), comprising intravitreally administering to an eye of the subject monthly or every other month a composition comprising pegcetacoplan, wherein: (a) the composition comprises about 15 mg/0.1 mL pegcetacoplan, and (b) visual function of the eye of the subject is maintained, or loss of visual function is reduced, relative to control. A control is level of visual function in a sham-treated subject (e.g., an untreated subject having the same level of risk and/or stage or severity of GA as the treated subject) or an average level of visual function in an untreated subject population.
Inventors:
FRANCOIS CEDRIC (US)
DESCHATELETS PASCAL (US)
GROSSI FEDERICO (US)
DESCHATELETS PASCAL (US)
GROSSI FEDERICO (US)
Application Number:
PCT/US2023/034207
Publication Date:
May 10, 2024
Filing Date:
September 29, 2023
Export Citation:
Assignee:
APELLIS PHARMACEUTICALS INC (US)
International Classes:
A61K38/10; A61K47/50; A61K47/54; A61K47/55
Attorney, Agent or Firm:
MEDINA, Rolando et al. (US)
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