Title:
THERAPEUTIC AGENT FOR RESPIRATORY DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/190976
Kind Code:
A1
Abstract:
Provided is a novel therapeutic agent that is useful for treating a chronic lung disease such as COPD or IPF. The present invention relates to a pharmaceutical composition for treating a chronic lung disease that contains a therapeutically effective amount of (R)-2-[3-[[N-(benzoxazol-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof or a solvate of the same.
Inventors:
ARAYA JUN (JP)
KUWANO KAZUYOSHI (JP)
ITO SABURO (JP)
MATSUBAYASHI SACHI (JP)
KUWANO KAZUYOSHI (JP)
ITO SABURO (JP)
MATSUBAYASHI SACHI (JP)
Application Number:
PCT/JP2023/013377
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
THE JIKEI UNIV (JP)
KOWA CO (JP)
KOWA CO (JP)
International Classes:
A61K31/423; A61P11/00; C07D263/58
Other References:
YAMASHITA SHIZUYA; MASUDA DAISAKU; MATSUZAWA YUJI: "Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases", CURRENT ATHEROSCLEROSIS REPORTS, SPRINGER US, NEW YORK, vol. 22, no. 1, 23 January 2020 (2020-01-23), New York, XP037022408, ISSN: 1523-3804, DOI: 10.1007/s11883-020-0823-5
M. SAMAH; ABD EL-RAHMAN EL-AIDY; MONA K. TAWFIK; MOHAMED M.S. EWAIS;: "Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 689, no. 1, 22 May 2012 (2012-05-22), NL , pages 186 - 193, XP028433345, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2012.05.026
KE QIAN; YANG LIN; CUI QINGHUA; DIAO WENQI; ZHANG YOUYI; XU MING; HE BEI: "Ciprofibrate attenuates airway remodeling in cigarette smoke-exposed rats", RESPIRATORY PHYSIOLOGY AND NEUROBIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 271, 13 September 2019 (2019-09-13), NL , XP085910760, ISSN: 1569-9048, DOI: 10.1016/j.resp.2019.103290
TAJIMA, SHUNJI ET AL.: "Effects of Bezafibrate on Bleomycin Pulmonary Fibrosis Model", JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY, NIHON KOKYUKI GAKKAI, TOKYO, JP, vol. 46, no. Suppl. 1, 1 January 2008 (2008-01-01), JP , pages 199, XP009549496, ISSN: 1343-3490
RYOTA KIKUCHI, YUKI IWAI, TAKAO TSUJI, YOSHIHIRO YAMAGUCHI, HIROYUKI NAKAMURA, KAZUTOSHI AOSHIBA: "PP58 Mechanism of suppressing pulmonary fibrosis via PPARα activation by fenofibrate", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY - NIHON-KOKYUKI-GAKKAI-ZASSHI, vol. 7, no. Suppl., 1 January 2018 (2018-01-01), pages 166, XP009549325, ISSN: 2186-5876
LIU YUANYUAN, CHEN SHUYU, YU LI, DENG YAO, LI DIFEI, YU XIU, CHEN DANDAN, LU YE, LIU SHENGMING, CHEN RONGCHANG: "Pemafibrate attenuates pulmonary fibrosis by inhibiting myofibroblast differentiation", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 108, 1 July 2022 (2022-07-01), NL , pages 108728, XP093094805, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2022.108728
M. SAMAH; ABD EL-RAHMAN EL-AIDY; MONA K. TAWFIK; MOHAMED M.S. EWAIS;: "Evaluation of the antifibrotic effect of fenofibrate and rosiglitazone on bleomycin-induced pulmonary fibrosis in rats", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 689, no. 1, 22 May 2012 (2012-05-22), NL , pages 186 - 193, XP028433345, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2012.05.026
KE QIAN; YANG LIN; CUI QINGHUA; DIAO WENQI; ZHANG YOUYI; XU MING; HE BEI: "Ciprofibrate attenuates airway remodeling in cigarette smoke-exposed rats", RESPIRATORY PHYSIOLOGY AND NEUROBIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 271, 13 September 2019 (2019-09-13), NL , XP085910760, ISSN: 1569-9048, DOI: 10.1016/j.resp.2019.103290
TAJIMA, SHUNJI ET AL.: "Effects of Bezafibrate on Bleomycin Pulmonary Fibrosis Model", JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY, NIHON KOKYUKI GAKKAI, TOKYO, JP, vol. 46, no. Suppl. 1, 1 January 2008 (2008-01-01), JP , pages 199, XP009549496, ISSN: 1343-3490
RYOTA KIKUCHI, YUKI IWAI, TAKAO TSUJI, YOSHIHIRO YAMAGUCHI, HIROYUKI NAKAMURA, KAZUTOSHI AOSHIBA: "PP58 Mechanism of suppressing pulmonary fibrosis via PPARα activation by fenofibrate", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY - NIHON-KOKYUKI-GAKKAI-ZASSHI, vol. 7, no. Suppl., 1 January 2018 (2018-01-01), pages 166, XP009549325, ISSN: 2186-5876
LIU YUANYUAN, CHEN SHUYU, YU LI, DENG YAO, LI DIFEI, YU XIU, CHEN DANDAN, LU YE, LIU SHENGMING, CHEN RONGCHANG: "Pemafibrate attenuates pulmonary fibrosis by inhibiting myofibroblast differentiation", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 108, 1 July 2022 (2022-07-01), NL , pages 108728, XP093094805, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2022.108728
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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