Title:
TERTIARY AMINE LIPID COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/125184
Kind Code:
A1
Abstract:
Provided are a tertiary amine lipid compound with a structure represented by formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof, and use thereof. The compound can damage a cell membrane or a lysosome membrane with high efficiency and selectivity, thus killing tumor cells.
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Inventors:
XIONG MENGHUA (CN)
ZHANG HOUBING (CN)
BAO YAN (CN)
LUO ZHIYI (CN)
WANG JUN (CN)
ZHANG HOUBING (CN)
BAO YAN (CN)
LUO ZHIYI (CN)
WANG JUN (CN)
Application Number:
PCT/CN2022/140623
Publication Date:
July 06, 2023
Filing Date:
December 21, 2022
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV (CN)
International Classes:
C07D209/00; A61K31/01; A61P35/00; C07D243/00
Domestic Patent References:
| WO2014210356A1 | 2014-12-31 |
Foreign References:
| CN104334161A | 2015-02-04 | |||
| CN113461577A | 2021-10-01 |
Other References:
MALAMAS, A.S. ET AL.: "Design and Evaluation of New pH-sensitive Amphiphilic Cationic Lipids for siRNA Delivery", JOURNAL OF CONTROLLED RELEASE, vol. 171, 21 June 2013 (2013-06-21), XP028740206, DOI: 10.1016/j.jconrel.2013.06.019
Attorney, Agent or Firm:
GUANGZHOU PRIME IP LAW OFFICE (CN)
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