Title:
TEMPERATURE-SENSITIVE GEL PHARMACEUTICAL COMPOSITION FOR TREATMENT OF TUMORS
Document Type and Number:
WIPO Patent Application WO/2021/042778
Kind Code:
A1
Abstract:
A temperature-sensitive gel pharmaceutical composition for treatment of tumors, characterized by comprising an active component and a gel forming adjuvant. The active component comprises a chemotherapeutic agent, or an immune adjuvant, or an immune checkpoint inhibitor that causes the immunogenic death of tumor cells. The gel forming adjuvant comprises a gel forming matrix. The gel forming matrix comprises natural biological materials: chitosan, dextran, cellulose, sodium alginate, and hyaluronic acid, and synthetic polymers: one or a plurality of poly-N-isopropylacrylamide copolymer, polyoxyethylene/polyoxypropylene, polyethylene glycol, polyvinyl alcohol, polylactic acid-glycolic acid copolymer, and polyethylene oxide sodium glycerophosphate. The preparation method of the temperature-sensitive gel pharmaceutical composition is simple, and the formation of the gel allows slow release of a drug.
Inventors:
LIU ZHUANG (CN)
TAO HUIQUAN (CN)
CHAO YU (CN)
ZHAO QI (CN)
TAO HUIQUAN (CN)
CHAO YU (CN)
ZHAO QI (CN)
Application Number:
PCT/CN2020/093378
Publication Date:
March 11, 2021
Filing Date:
May 29, 2020
Export Citation:
Assignee:
SUZHOU INNOVATIVE BIOMATERIALS & PHARMACEUTICS CO LTD (CN)
International Classes:
A61K9/00; A61K47/10; A61K47/36; A61K47/38; A61K47/58; A61K47/60; A61P35/00
Domestic Patent References:
| WO2018045058A1 | 2018-03-08 | |||
| WO2018045058A1 | 2018-03-08 |
Foreign References:
| US20080044452A1 | 2008-02-21 | |||
| CN102988274A | 2013-03-27 | |||
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| CN101176706A | 2008-05-14 | |||
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| CN107099042A | 2017-08-29 | |||
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| CN109464395A | 2019-03-15 |
Attorney, Agent or Firm:
SUZHOU JIANLI INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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