Title:
TAXAMAIRIN ANALOGS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/221981
Kind Code:
A1
Abstract:
Taxamairin and analogs thereof useful in the treatment of inflammatory diseases or conditions, such as inflammatory bowel disease, pharmaceutical compositions including the same, and methods of use and preparation thereof.
Inventors:
TAI CHI SHING (CN)
Application Number:
PCT/CN2023/094556
Publication Date:
November 23, 2023
Filing Date:
May 16, 2023
Export Citation:
Assignee:
BP APOLLO LTD (CN)
International Classes:
C07C211/32; A61P29/00; C07C35/37; C07C43/20; C07C49/665
Foreign References:
| CN101223153A | 2008-07-16 |
Other References:
DATABASE Registry 24 February 1998 (1998-02-24), ANONYMOUS: "10H-Dibenzo[a,d]cyclohepten-10-one, 1,2,3,4,4a,5,11,11a-octahydro-1,1-dimethyl-8-(1-methylethyl)-, (4aR,11aR)-rel- (CA INDEX NAME)", XP093108183, retrieved from STNext Database accession no. 201726-44-5
DATABASE STNext 23 November 1985 (1985-11-23), ANONYMOUS: "1H-Dibenzo[a,d]cyclohepten-7-ol, 2,3,4,4a,5,10,11,11a-octahydro-1,1- dimethyl-8-(1-methylethyl)- (CA INDEX NAME)", XP093108184, retrieved from STNext Database accession no. 99152-28-0
KELECOM ALPHONSE, DE NCCLEO: "Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with a rearranged abietane skeleton from the labiate coleus barbatus", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 21, 1 January 1983 (1983-01-01), AMSTERDAM, NL , pages 3603 - 3608, XP093108180, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)88671-3
HASEGAWA SHINICHI, KOJIMA TOSHIMI, HIROSE YOSHIYUKI: "Terpenoids from the seed of Chamaecyparis pisifera: the structures of six diterpenoids", PHYTOCHEMISTRY, vol. 24, no. 7, 31 December 1985 (1985-12-31), pages 1545 - 1551, XP093108181
NYTOFT HANS PETER; KILDAHL-ANDERSEN GEIR; LINDSTRöM SOFIE; RISE FRODE; BECHTEL ACHIM; MITROVIć DANICA; ĐOKOVIć: "Dehydroicetexanes in sediments and crude oils: Possible markers for Cupressoideae", ORGANIC GEOCHEMISTRY, PERGAMON, AMSTERDAM, NL, vol. 129, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 14 - 23, XP085627070, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.01.001
ABDUL-WAHAB SALAE; APINYA RODJUN; CHATCHANOK KARALAI; CHANITA PONGLIMANONT; SUCHADA CHANTRAPROMMA; AKKHARAWIT KANJANA-OPAS; SUPINY: "Potential anti-inflammatory diterpenes from", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 68, no. 3, 21 November 2011 (2011-11-21), AMSTERDAM, NL , pages 819 - 829, XP028339466, ISSN: 0040-4020, DOI: 10.1016/j.tet.2011.11.058
XU JING, WANG MEICHENG, SUN XIAOCONG, REN QUANHUI, CAO XIANGRONG, LI SHEN, SU GUOCHEN, TUERHONG MUHETAER, LEE DONGHO, OHIZUMI YASU: "Bioactive Terpenoids from Salvia plebeia : Structures, NO Inhibitory Activities, and Interactions with iNOS", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 11, 23 November 2016 (2016-11-23), US , pages 2924 - 2932, XP093108182, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00733
DATABASE STNext 23 November 1985 (1985-11-23), ANONYMOUS: "1H-Dibenzo[a,d]cyclohepten-7-ol, 2,3,4,4a,5,10,11,11a-octahydro-1,1- dimethyl-8-(1-methylethyl)- (CA INDEX NAME)", XP093108184, retrieved from STNext Database accession no. 99152-28-0
KELECOM ALPHONSE, DE NCCLEO: "Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with a rearranged abietane skeleton from the labiate coleus barbatus", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 21, 1 January 1983 (1983-01-01), AMSTERDAM, NL , pages 3603 - 3608, XP093108180, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)88671-3
HASEGAWA SHINICHI, KOJIMA TOSHIMI, HIROSE YOSHIYUKI: "Terpenoids from the seed of Chamaecyparis pisifera: the structures of six diterpenoids", PHYTOCHEMISTRY, vol. 24, no. 7, 31 December 1985 (1985-12-31), pages 1545 - 1551, XP093108181
NYTOFT HANS PETER; KILDAHL-ANDERSEN GEIR; LINDSTRöM SOFIE; RISE FRODE; BECHTEL ACHIM; MITROVIć DANICA; ĐOKOVIć: "Dehydroicetexanes in sediments and crude oils: Possible markers for Cupressoideae", ORGANIC GEOCHEMISTRY, PERGAMON, AMSTERDAM, NL, vol. 129, 1 January 1900 (1900-01-01), AMSTERDAM, NL , pages 14 - 23, XP085627070, ISSN: 0146-6380, DOI: 10.1016/j.orggeochem.2019.01.001
ABDUL-WAHAB SALAE; APINYA RODJUN; CHATCHANOK KARALAI; CHANITA PONGLIMANONT; SUCHADA CHANTRAPROMMA; AKKHARAWIT KANJANA-OPAS; SUPINY: "Potential anti-inflammatory diterpenes from", TETRAHEDRON, ELSEVIER SIENCE PUBLISHERS, AMSTERDAM, NL, vol. 68, no. 3, 21 November 2011 (2011-11-21), AMSTERDAM, NL , pages 819 - 829, XP028339466, ISSN: 0040-4020, DOI: 10.1016/j.tet.2011.11.058
XU JING, WANG MEICHENG, SUN XIAOCONG, REN QUANHUI, CAO XIANGRONG, LI SHEN, SU GUOCHEN, TUERHONG MUHETAER, LEE DONGHO, OHIZUMI YASU: "Bioactive Terpenoids from Salvia plebeia : Structures, NO Inhibitory Activities, and Interactions with iNOS", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 79, no. 11, 23 November 2016 (2016-11-23), US , pages 2924 - 2932, XP093108182, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00733
Attorney, Agent or Firm:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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