Title:
SYSTEM FOR CONTROLLING VIRUS REPLICATION IN RESPONSE TO HYPOXIC ENVIRONMENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/082263
Kind Code:
A1
Abstract:
Provided are a system for controlling virus replication in response to a hypoxic environment and use thereof. The system comprises: a gene encoding an hypoxia response element, a gene encoding a virus transcription factor recognition element, and one or more genes encoding a virus inhibition factor, wherein said genes are connected in sequence. The system allows the virus inhibition factor, which is a product of a gene of interest, to be expressed in a normal oxygen environment, and to be low-expressed or not expressed in a hypoxic environment, so that the specific killing effect of oncolytic viruses on cancer cells is exerted, thereby improving the curative effect of oncolytic viruses in the treatment of hypoxic diseases such as solid tumors.
Inventors:
XU JIANQING (CN)
ZHANG XIAOYAN (CN)
DING XIANGQING (CN)
LIAO QIBIN (CN)
ZHANG XIAOYAN (CN)
DING XIANGQING (CN)
LIAO QIBIN (CN)
Application Number:
PCT/CN2022/126657
Publication Date:
April 25, 2024
Filing Date:
October 21, 2022
Export Citation:
Assignee:
SHANGHAI SINOBAY BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12N15/863; A61K35/768; A61K38/21; A61P35/00; A61P35/02; C12N7/01; C12N15/12; C12N15/22; C12N15/23; C12R1/93
Foreign References:
| US20050074430A1 | 2005-04-07 | |||
| CN112921035A | 2021-06-08 | |||
| CN111394320A | 2020-07-10 | |||
| CN111763660A | 2020-10-13 | |||
| US20210252135A1 | 2021-08-19 | |||
| US20220064670A1 | 2022-03-03 |
Other References:
ALI ZAHEDI-AMIRI: "Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer", CELLS, MDPI AG, vol. 10, no. 10, 6 October 2021 (2021-10-06), pages 2672, XP093159556, ISSN: 2073-4409, DOI: 10.3390/cells10102672
DRORY S TENDLER: "Intersection of Interferon and Hypoxia Signal Transduction Pathways in Nitric Oxide-induced Tumor Apoptosis 1", CANCER RESEARCH, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3682 - 3688, XP093159559
DRORY S TENDLER: "Intersection of Interferon and Hypoxia Signal Transduction Pathways in Nitric Oxide-induced Tumor Apoptosis 1", CANCER RESEARCH, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3682 - 3688, XP093159559
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (CN)
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