Title:
SYNTHESIS OF CYCLOPROPANE CARBOXYLIC ACIDS
Document Type and Number:
WIPO Patent Application WO/2024/064214
Kind Code:
A3
Abstract:
The present disclosure provides methods of preparing substituted cyclopropane compounds.
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Inventors:
PAPAIOANNOU NIKOLAOS (US)
FRAY MICHAEL JONATHAN (GB)
RENNHACK ANDREAS (GB)
FINK SARAH JOCELYN (US)
FRAY MICHAEL JONATHAN (GB)
RENNHACK ANDREAS (GB)
FINK SARAH JOCELYN (US)
Application Number:
PCT/US2023/033264
Publication Date:
May 02, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
PAPAIOANNOU NIKOLAOS (US)
FRAY MICHAEL JONATHAN (GB)
RENNHACK ANDREAS (GB)
FINK SARAH JOCELYN (US)
PAPAIOANNOU NIKOLAOS (US)
FRAY MICHAEL JONATHAN (GB)
RENNHACK ANDREAS (GB)
FINK SARAH JOCELYN (US)
International Classes:
C07D239/26; C07D403/12; C07D471/04
Domestic Patent References:
| WO2018183956A1 | 2018-10-04 | |||
| WO2022197758A1 | 2022-09-22 |
Other References:
CHEN YING ET AL: "Asymmetric Cyclopropanation of Styrenes Catalyzed by Metal Complexes of D 2 -Symmetrical Chiral Porphyrin:? Superiority of Cobalt over Iron", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 72, no. 15, 23 June 2007 (2007-06-23), pages 5931 - 5934, XP093114466, ISSN: 0022-3263, DOI: 10.1021/jo070997p
LV LEIYANG ET AL: "Ruthenium catalyzed [beta]-selective alkylation of vinylpyridines with aldehydes/ketones via N 2 H 4 mediated deoxygenative couplings", CHEMICAL SCIENCE, vol. 12, no. 8, 1 January 2021 (2021-01-01), United Kingdom, pages 2870 - 2875, XP093114606, ISSN: 2041-6520, DOI: 10.1039/D0SC06586B
YAMAKI SUSUMU ET AL: "Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, no. 21, 23 September 2017 (2017-09-23), pages 6024 - 6038, XP085244128, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2017.09.036
FRAY M. JONATHAN ET AL: "N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid", ORGANIC PROCESS RESEARCH & DEVELOPMENT, 15 August 2023 (2023-08-15), US, XP093114449, ISSN: 1083-6160, Retrieved from the Internet DOI: 10.1021/acs.oprd.3c00175
LV LEIYANG ET AL: "Ruthenium catalyzed [beta]-selective alkylation of vinylpyridines with aldehydes/ketones via N 2 H 4 mediated deoxygenative couplings", CHEMICAL SCIENCE, vol. 12, no. 8, 1 January 2021 (2021-01-01), United Kingdom, pages 2870 - 2875, XP093114606, ISSN: 2041-6520, DOI: 10.1039/D0SC06586B
YAMAKI SUSUMU ET AL: "Synthesis and structure activity relationships of carbamimidoylcarbamate derivatives as novel vascular adhesion protein-1 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 25, no. 21, 23 September 2017 (2017-09-23), pages 6024 - 6038, XP085244128, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2017.09.036
FRAY M. JONATHAN ET AL: "N-Ylide Mediated Synthesis and Resolution of a Chiral Pyrimidinyl Cyclopropane Carboxylic Acid", ORGANIC PROCESS RESEARCH & DEVELOPMENT, 15 August 2023 (2023-08-15), US, XP093114449, ISSN: 1083-6160, Retrieved from the Internet
Attorney, Agent or Firm:
BUTEAU, Kristen C. et al. (US)
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