Title:
STING PATHWAY MODULATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/037179
Kind Code:
A1
Abstract:
A compound of formula I or a pharmaceutically acceptable salt, solvate, or prodrug thereof, a preparation method therefor, a pharmaceutical composition comprising same, and an application thereof. The compound can be used to prepare a drug for treating or preventing a disease related to STING pathway.
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Inventors:
ZHAO HAIFENG (CN)
Application Number:
PCT/CN2020/111932
Publication Date:
March 04, 2021
Filing Date:
August 27, 2020
Export Citation:
Assignee:
MEDSPRING INT LTD (CN)
International Classes:
C07D219/06; A61K31/473; A61P29/00; A61P31/00; A61P35/00; C07D471/06
Domestic Patent References:
| WO2019100061A1 | 2019-05-23 |
Foreign References:
| EP0857721A1 | 1998-08-12 |
Other References:
HOU SHI; LAN XIU-JUAN; LI WEI; YAN XIN-LIN; CHANG JIA-JIA; YANG XIAO-HONG; SUN WEI; XIAO JUN-HAI; LI SONG: "Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists", BIOORGANIC CHEMISTRY, vol. 95, 30 December 2019 (2019-12-30), US, pages 1 - 13, XP086005459, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2019.103556
NAKAMURA SEIKOU; KOZUKA MUTSUO; BASTOW KENNETH F.; TOKUDA HARUKUNI; NISHINO HOYOKU; SUZUKI MADOKA; TATSUZAKI JIN; MORRIS NATSCHKE : "Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 14, 1 January 1900 (1900-01-01), pages 4396 - 4401, XP029174196, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2005.04.078
SWARNA A. GAMAGE, GORDON W. REWCASTLE, GRAHAM J. ATWELL, BRUCE C. BAGULEY, WILLIAM A. DENNY: "Structure-activity relationships for substituted 9-oxo-9, 10-dihydroacridine-4-acetic acids:analogues of the colon tumor active agent xanthenone-4-acetic acid", ANTI-CANCER DRUG DESIGN, vol. 7, 31 December 1992 (1992-12-31), pages 403 - 414, XP009526477, ISSN: 0266-9536
REWCASTLE, GORDON W.; DENNY, WILLIAM A.: "The synthesis of substituted 9-oxoacridan-4-carboxylic acids; Part 2.The Use of 2-Iodoisophthalic Acid in the Jourdan-Ullmann Reaction", SYNTHESIS, no. 2, 28 February 1985 (1985-02-28), pages 217 - 220, XP009526478, ISSN: 0039-7881, DOI: 10.1055/s-1985-31164
NAKAMURA SEIKOU; KOZUKA MUTSUO; BASTOW KENNETH F.; TOKUDA HARUKUNI; NISHINO HOYOKU; SUZUKI MADOKA; TATSUZAKI JIN; MORRIS NATSCHKE : "Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 14, 1 January 1900 (1900-01-01), pages 4396 - 4401, XP029174196, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2005.04.078
SWARNA A. GAMAGE, GORDON W. REWCASTLE, GRAHAM J. ATWELL, BRUCE C. BAGULEY, WILLIAM A. DENNY: "Structure-activity relationships for substituted 9-oxo-9, 10-dihydroacridine-4-acetic acids:analogues of the colon tumor active agent xanthenone-4-acetic acid", ANTI-CANCER DRUG DESIGN, vol. 7, 31 December 1992 (1992-12-31), pages 403 - 414, XP009526477, ISSN: 0266-9536
REWCASTLE, GORDON W.; DENNY, WILLIAM A.: "The synthesis of substituted 9-oxoacridan-4-carboxylic acids; Part 2.The Use of 2-Iodoisophthalic Acid in the Jourdan-Ullmann Reaction", SYNTHESIS, no. 2, 28 February 1985 (1985-02-28), pages 217 - 220, XP009526478, ISSN: 0039-7881, DOI: 10.1055/s-1985-31164
Attorney, Agent or Firm:
SPREADWINGS INTELLECTUAL PROPERTY AGENCY LTD (CN)
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