Title:
SIRTUIN ACTIVATOR OR EXPRESSION ENHANCER, NAD+ INCREASING AGENT, AND SENESCENT CELL INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2024/080323
Kind Code:
A1
Abstract:
Provided is a novel use of a composition that contains a prescribed sulfur-containing compound, a salt thereof, or both. The present invention is a sirtuin activator or expression enhancer, a NAD+ increasing agent, or a senescent cell inhibitor containing, as an active ingredient, a compound (excluding S-1-propenylcysteine) represented by general formula 1A or 1B, or a salt thereof.
Inventors:
SUZUKI JUNICHIRO (JP)
NAKAMOTO MASATO (JP)
NAKAMOTO MASATO (JP)
Application Number:
PCT/JP2023/036962
Publication Date:
April 18, 2024
Filing Date:
October 12, 2023
Export Citation:
Assignee:
WAKUNAGA PHARMA CO LTD (JP)
International Classes:
A61K31/198; A23L33/10; A61K31/54; A61P1/16; A61P9/00; A61P13/12; A61P25/00; A61P25/28; A61P43/00
Domestic Patent References:
| WO2023199967A1 | 2023-10-19 | |||
| WO2022220265A1 | 2022-10-20 |
Other References:
YI-CHEN CHEN: "Methanolic extract of black garlic ameliorates diet-induced obesity via regulating adipogenesis, adipokine biosynthesis, and lipolysis", JOURNAL OF FUNCTIONAL FOODS, ELSEVIER BV, NL, vol. 9, 1 July 2014 (2014-07-01), NL , pages 98 - 108, XP093157853, ISSN: 1756-4646, DOI: 10.1016/j.jff.2014.02.019
PACE E.; DI VINCENZO S.; FERRARO M.; BRUNO A.; DINO P.; BONSIGNORE M.R.; BATTAGLIA S.; SAIBENE F.; LANATA L.; GJOMARKAJ M.: "Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells", EXPERIMENTAL GERONTOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 81, 26 May 2016 (2016-05-26), AMSTERDAM, NL , pages 119 - 128, XP029627686, ISSN: 0531-5565, DOI: 10.1016/j.exger.2016.05.013
ZAHRA ARAB SADEGHABADI , NASRIN ZIAMAJIDI, ROGHAYEH ABBASALIPOURKABIR, ROOHOLLAH MOHSENI: "Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats", JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY, FREUND PUBLISHING HOUSE LTD., LONDON, GB, vol. 29, no. 5, 19 April 2018 (2018-04-19), GB , pages 463 - 467, XP009540302, ISSN: 0792-6855, DOI: 10.1515/jbcpp-2017-0079
ZHONG LIN, HUANG FEI, SHI HAILIAN, WU HUI, ZHANG BEIBEI, WU XIAOJUN, WEI XIAOHUI, WANG ZHENGTAO: "Qing'E formula alleviates the aging process in D-galactose-induced aging mice", BIOMEDICAL REPORTS MAY 2014 SPANDIDOS PUBLICATIONS GBR, SPANDIDOS PUBLICATIONS, GREECE, vol. 5, no. 1, 1 July 2016 (2016-07-01), Greece , pages 101 - 106, XP055976634, ISSN: 2049-9434, DOI: 10.3892/br.2016.667
TORU MORIGUCHI, HIROSHI SAITO, NOBUYOSHI NISHIYAMA: "Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 19, no. 2, 1 February 1996 (1996-02-01), JP , pages 305 - 307, XP008056754, ISSN: 0918-6158, DOI: 10.1248/bpb.19.305
KUBEC, R. ; DADAKOVA, E.: "Chromatographic methods for determination of S-substituted cysteine derivatives-A comparative study", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 1216, no. 41, 9 October 2009 (2009-10-09), AMSTERDAM, NL, pages 6957 - 6963, XP026611728, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2009.08.032
TAKUTO FUJII: "Changes of S -Allylmercaptocysteine and γ-Glutamyl- S -allylmercaptocysteine Contents and Their Putative Production Mechanisms in Garlic Extract during the Aging Process", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 66, no. 40, 10 October 2018 (2018-10-10), US , pages 10506 - 10512, XP093157857, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b02541
MAKOTO ICHIKAWA: "Pharmacokinetics of Cycloalliin, an Organosulfur Compound Found in Garlic and Onion, in Rats", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 54, no. 26, 1 December 2006 (2006-12-01), US , pages 9811 - 9819, XP093157858, ISSN: 0021-8561, DOI: 10.1021/jf062252a
YUKIHIORO KODERA, USHIJIMA MITSUYASU, AMANO HIROTAKA, SUZUKI JUN-ICHIRO, MATSUTOMO TOSHIAKI: "Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract", MOLECULES, vol. 22, no. 4, 31 March 2017 (2017-03-31), pages 1 - 18, XP055576029, DOI: 10.3390/molecules22040570
PACE E.; DI VINCENZO S.; FERRARO M.; BRUNO A.; DINO P.; BONSIGNORE M.R.; BATTAGLIA S.; SAIBENE F.; LANATA L.; GJOMARKAJ M.: "Carbocysteine counteracts the effects of cigarette smoke on cell growth and on the SIRT1/FoxO3 axis in bronchial epithelial cells", EXPERIMENTAL GERONTOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 81, 26 May 2016 (2016-05-26), AMSTERDAM, NL , pages 119 - 128, XP029627686, ISSN: 0531-5565, DOI: 10.1016/j.exger.2016.05.013
ZAHRA ARAB SADEGHABADI , NASRIN ZIAMAJIDI, ROGHAYEH ABBASALIPOURKABIR, ROOHOLLAH MOHSENI: "Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats", JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY, FREUND PUBLISHING HOUSE LTD., LONDON, GB, vol. 29, no. 5, 19 April 2018 (2018-04-19), GB , pages 463 - 467, XP009540302, ISSN: 0792-6855, DOI: 10.1515/jbcpp-2017-0079
ZHONG LIN, HUANG FEI, SHI HAILIAN, WU HUI, ZHANG BEIBEI, WU XIAOJUN, WEI XIAOHUI, WANG ZHENGTAO: "Qing'E formula alleviates the aging process in D-galactose-induced aging mice", BIOMEDICAL REPORTS MAY 2014 SPANDIDOS PUBLICATIONS GBR, SPANDIDOS PUBLICATIONS, GREECE, vol. 5, no. 1, 1 July 2016 (2016-07-01), Greece , pages 101 - 106, XP055976634, ISSN: 2049-9434, DOI: 10.3892/br.2016.667
TORU MORIGUCHI, HIROSHI SAITO, NOBUYOSHI NISHIYAMA: "Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse", BIOLOGICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, vol. 19, no. 2, 1 February 1996 (1996-02-01), JP , pages 305 - 307, XP008056754, ISSN: 0918-6158, DOI: 10.1248/bpb.19.305
KUBEC, R. ; DADAKOVA, E.: "Chromatographic methods for determination of S-substituted cysteine derivatives-A comparative study", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 1216, no. 41, 9 October 2009 (2009-10-09), AMSTERDAM, NL, pages 6957 - 6963, XP026611728, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2009.08.032
TAKUTO FUJII: "Changes of S -Allylmercaptocysteine and γ-Glutamyl- S -allylmercaptocysteine Contents and Their Putative Production Mechanisms in Garlic Extract during the Aging Process", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 66, no. 40, 10 October 2018 (2018-10-10), US , pages 10506 - 10512, XP093157857, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.8b02541
MAKOTO ICHIKAWA: "Pharmacokinetics of Cycloalliin, an Organosulfur Compound Found in Garlic and Onion, in Rats", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 54, no. 26, 1 December 2006 (2006-12-01), US , pages 9811 - 9819, XP093157858, ISSN: 0021-8561, DOI: 10.1021/jf062252a
YUKIHIORO KODERA, USHIJIMA MITSUYASU, AMANO HIROTAKA, SUZUKI JUN-ICHIRO, MATSUTOMO TOSHIAKI: "Chemical and Biological Properties of S-1-Propenyl-ʟ-Cysteine in Aged Garlic Extract", MOLECULES, vol. 22, no. 4, 31 March 2017 (2017-03-31), pages 1 - 18, XP055576029, DOI: 10.3390/molecules22040570
Attorney, Agent or Firm:
NIIYAMA Yuichi et al. (JP)
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