Title:
SIMPLE PREPARATION METHOD FOR AND APPLICATION OF ULTRA-SMALL SELENIUM NANOPARTICLE-LOADED METAL FRAMEWORK COMPOSITE
Document Type and Number:
WIPO Patent Application WO/2023/082216
Kind Code:
A1
Abstract:
An ultra-small selenium nanoparticle-loaded metal-organic framework composite, and a preparation method therefor and an application thereof. The method comprises: adding PEG 400 and selenium powder into a beaker, and stirring after sonication to uniformly disperse the selenium powder in the PEG 400; transferring the beaker to a magnetic stirrer, stirring while heating, naturally cooling after reacting for a certain period of time, transferring into a centrifugal tube for centrifuging, obtaining a supernate after centrifuging, and finally obtaining PEG-SeNPs; and preparing a selenium nanoparticle-loaded metal-organic framework composite by using raw materials comprising the PEG-SeNPs and a metal salt solution, and suspending the selenium nanoparticle-loaded metal-organic framework composite in a buffer solution. The ultra-small selenium nanoparticle-loaded metal-organic framework composite has an effect of effectively scavenging free radicals, and good oxidation resistance, and can effectively reverse damage caused by oxidative stress, and relieve brain damage caused after cerebral ischemia reperfusion.
Inventors:
CHEN TIANFENG (CN)
HE LIZHEN (CN)
CHEN YIKANG (CN)
HUANG GUANNING (CN)
LI HAIWEI (CN)
DAI ZHENMEI (CN)
HE LIZHEN (CN)
CHEN YIKANG (CN)
HUANG GUANNING (CN)
LI HAIWEI (CN)
DAI ZHENMEI (CN)
Application Number:
PCT/CN2021/130489
Publication Date:
May 19, 2023
Filing Date:
November 13, 2021
Export Citation:
Assignee:
GUANGDONG JINAN SELENIUM SOURCE NANOTECHNOLOGY RES INSTITUTE CO LTD (CN)
International Classes:
A61K47/69; A61K33/04; A61P9/10; A61P39/06; B82Y5/00; B82Y30/00; B82Y40/00; C08G83/00
Foreign References:
| CN105030820A | 2015-11-11 | |||
| CN109444435A | 2019-03-08 | |||
| CN106692181A | 2017-05-24 |
Other References:
ZHENG LUO; LU JIANG; SHAOXIONG YANG; ZIBIAO LI; WEE MIA WILSON SOH; LIYAN ZHENG; XIAN JUN LOH; YUN‐LONG WU: "Light‐Induced Redox‐Responsive Smart Drug Delivery System by Using Selenium‐Containing Polymer@MOF Shell/Core Nanocomposite", ADVANCED HEALTHCARE MATERIALS, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, vol. 8, no. 15, 11 June 2019 (2019-06-11), DE , pages 1 - 13, XP072468780, ISSN: 2192-2640, DOI: 10.1002/adhm.201900406
AMANI HAMED, HABIBEY ROUHOLLAH, SHOKRI FERESHTEH, HAJMIRESMAIL SEYED JAVAD, AKHAVAN OMID, MASHAGHI ALIREZA, PAZOKI-TOROUDI HAMIDRE: "Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling", SCIENTIFIC REPORTS, vol. 9, no. 1, 15 April 2019 (2019-04-15), pages 6044, XP093065369, DOI: 10.1038/s41598-019-42633-9
GIMÉNEZ-MARQUÉS MÓNICA, BELLIDO ELENA, BERTHELOT THOMAS, SIMÓN-YARZA TERESA, HIDALGO TANIA, SIMÓN-VÁZQUEZ ROSANA, GONZÁLEZ-FERNÁND: "GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness", SMALL, WILEY, HOBOKEN, USA, vol. 14, no. 40, 1 October 2018 (2018-10-01), Hoboken, USA, pages 1801900, XP093065371, ISSN: 1613-6810, DOI: 10.1002/smll.201801900
"Master's Thesis", 1 March 2020, WUHAN UNIVERSITY, CN, article GUO QIAO: "Study on the Application of Rapamycin to Ischemic Stroke in Mice with Nano-metal Organic Framework", pages: 1 - 41, XP009545534, DOI: 10.27379/d.cnki.gwhdu.2020.000436
AMANI HAMED, HABIBEY ROUHOLLAH, SHOKRI FERESHTEH, HAJMIRESMAIL SEYED JAVAD, AKHAVAN OMID, MASHAGHI ALIREZA, PAZOKI-TOROUDI HAMIDRE: "Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling", SCIENTIFIC REPORTS, vol. 9, no. 1, 15 April 2019 (2019-04-15), pages 6044, XP093065369, DOI: 10.1038/s41598-019-42633-9
GIMÉNEZ-MARQUÉS MÓNICA, BELLIDO ELENA, BERTHELOT THOMAS, SIMÓN-YARZA TERESA, HIDALGO TANIA, SIMÓN-VÁZQUEZ ROSANA, GONZÁLEZ-FERNÁND: "GraftFast Surface Engineering to Improve MOF Nanoparticles Furtiveness", SMALL, WILEY, HOBOKEN, USA, vol. 14, no. 40, 1 October 2018 (2018-10-01), Hoboken, USA, pages 1801900, XP093065371, ISSN: 1613-6810, DOI: 10.1002/smll.201801900
"Master's Thesis", 1 March 2020, WUHAN UNIVERSITY, CN, article GUO QIAO: "Study on the Application of Rapamycin to Ischemic Stroke in Mice with Nano-metal Organic Framework", pages: 1 - 41, XP009545534, DOI: 10.27379/d.cnki.gwhdu.2020.000436
Attorney, Agent or Firm:
GUANGZHOU RUIJINZE PATENT AGENCY (CN)
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