Title:
SIDE EFFECT REDUCING AGENT FOR NUCLEIC ACID DRUG, MEDICINAL COMPOSITION COMPRISING SIDE EFFECT REDUCING AGENT FOR NUCLEIC ACID DRUG, AND METHOD FOR REDUCING SIDE EFFECT INDUCING PROPERTIES OF NUCLEIC ACID DRUG
Document Type and Number:
WIPO Patent Application WO/2020/262555
Kind Code:
A1
Abstract:
A side effect reducing agent for a nucleic acid drug that comprises an oligopeptide containing an oligopeptide domain, said oligopeptide domain consisting of 2-40 amino acids and including a structure W that has two or more specific consecutive amino acid residues, wherein, when the oligopeptide domain includes two or more structures W therein, then adjacent structures W are linked to each other via one amino acid residue X that is not represented by formula (I), and the oligopeptide domain is composed of either a single structure W or two or more structures W with the amino acid residue X.
Inventors:
YOKOTA TAKANORI (JP)
NAGATA TETSUYA (JP)
HARA RINTARO (JP)
OHARA MASAHIRO (JP)
WADA TAKESHI (JP)
SATO KAZUKI (JP)
MAEDA YUSUKE (JP)
TAKAGI KAZUNORI (JP)
NAGATA TETSUYA (JP)
HARA RINTARO (JP)
OHARA MASAHIRO (JP)
WADA TAKESHI (JP)
SATO KAZUKI (JP)
MAEDA YUSUKE (JP)
TAKAGI KAZUNORI (JP)
Application Number:
PCT/JP2020/025093
Publication Date:
December 30, 2020
Filing Date:
June 25, 2020
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
UNIV TOKYO SCIENCE FOUND (JP)
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
A61P39/04; A61K31/7088; A61K38/08; A61K38/10; A61K47/42; A61P43/00; C07K2/00; C12N15/113
Domestic Patent References:
| WO2019013255A1 | 2019-01-17 | |||
| WO2014148620A1 | 2014-09-25 |
Other References:
MAEDA, Y ET AL.: "S ynthesis and properties of cationic oligopeptides with different side chain lengths that bind to RNA duplexes", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 7, 2013, pages 1717 - 1723, XP029002608, DOI: 10.1016/j.bmc.2013.01.053
MAEDA YUSUKE, IWATA HARA RINTARO, NISHINA KAZUTAKA, YOSHIDA-TANAKA KIE, SAKAMOTO TAIICHI, YOKOTA TAKANORI, WADA TAKESHI: "Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity", NUCLEOSIDES , NUCLEOTIDES AND NUCLEIC ACIDS, vol. 38, no. 5, 2019, pages 338 - 348, XP055778723
HARA RINTARO IWATA, MAEDA YUSUKE, FUJIMAKI HARUNA, WADA TAKESHI: "Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides", CHEM COMMUN, vol. 54, no. 61, 2018, pages 8526 - 8529, XP055778726
MAEDA YUSUKE, IWATA HARA RINTARO, NISHINA KAZUTAKA, YOSHIDA-TANAKA KIE, SAKAMOTO TAIICHI, YOKOTA TAKANORI, WADA TAKESHI: "Artificial cationic peptides that increase nuclease resistance of siRNA without disturbing RNAi activity", NUCLEOSIDES , NUCLEOTIDES AND NUCLEIC ACIDS, vol. 38, no. 5, 2019, pages 338 - 348, XP055778723
HARA RINTARO IWATA, MAEDA YUSUKE, FUJIMAKI HARUNA, WADA TAKESHI: "Enhancement in RNase H activity of a DNA/RNA hybrid duplex using artificial cationic oligopeptides", CHEM COMMUN, vol. 54, no. 61, 2018, pages 8526 - 8529, XP055778726
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
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