Title:
RADIOACTIVE COMPLEX OF ANTI-CD20 ANTIBODY, AND RADIOPHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2022/224980
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a complex that has higher stability than in the past without reducing drug efficacy. The complex of the present invention is a complex of an anti-CD20 antibody and a chelating agent, wherein: a radiometal nuclide is chelated to the chelating agent; the anti-CD20 antibody and the chelating agent are linked via a linker (L); and the linker (L) does not contain a thiourea bond.
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Inventors:
KAWATANI MINORU (JP)
TAKENAKA FUMIAKI (JP)
HANADA TAKAHISA (JP)
TONOYA GOTA (JP)
TAKEDA TAKUYA (JP)
TAKENAKA FUMIAKI (JP)
HANADA TAKAHISA (JP)
TONOYA GOTA (JP)
TAKEDA TAKUYA (JP)
Application Number:
PCT/JP2022/018246
Publication Date:
October 27, 2022
Filing Date:
April 20, 2022
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
A61K47/68; A61K39/395; A61K45/00; A61K47/60; A61K47/69; A61K51/00; A61K51/02; A61K51/10; A61P35/00; C07K4/00; C07K16/28
Domestic Patent References:
| WO2019203191A1 | 2019-10-24 | |||
| WO2021075546A1 | 2021-04-22 | |||
| WO2021075544A1 | 2021-04-22 | |||
| WO2004032828A2 | 2004-04-22 | |||
| WO2016186206A1 | 2016-11-24 | |||
| WO2017217347A1 | 2017-12-21 | |||
| WO2018230257A1 | 2018-12-20 | |||
| WO2021080008A1 | 2021-04-29 |
Foreign References:
| JP2006511532A | 2006-04-06 | |||
| US5736137A | 1998-04-07 | |||
| JP2021071320A | 2021-05-06 | |||
| JP2022030389A | 2022-02-18 |
Other References:
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XIE QINGHUA, ZHU HUA, WANG FENG, MENG XIANGXI, REN QIUSHI, XIA CHUANQIN, YANG ZHI: "Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging", MOLECULES, vol. 22, no. 4, 17 April 2017 (2017-04-17), XP055979116, DOI: 10.3390/molecules22040641
BOGDAN MITRAN; SARA S. RINNE; MARK W. KONIJNENBERG; THEODOSIA MAINA; BERTHOLD A. NOCK; MOHAMED ALTAI; ANZHELIKA VOROBYEVA; MATS LA: "Trastuzumab cotreatment improves survival of mice with PC‐3 prostate cancer xenografts treated with the GRPR antagonist 177Lu‐DOTAGA‐PEG2‐RM26", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 145, no. 12, 23 May 2019 (2019-05-23), US , pages 3347 - 3358, XP071290851, ISSN: 0020-7136, DOI: 10.1002/ijc.32401
BERNHARD ET AL.: "DOTAGA-Anhydride: A Valuable Building Block for the Preparation of DOTA-Like Chelating Agents Chem", EUR. J, vol. 18, 2012, pages 7834 - 7841, XP055465245, DOI: 10.1002/chem.201200132
DAHLE, J. BORREBAEK, J. MELHUS, K.B. BRULAND, O.S. SALBERG, G. OLSEN, D.R. LARSEN, R.H.: "Initial evaluation of ^2^2^7Th-p-benzyl-DOTA-rituximab for low-dose rate @a-particle radioimmunotherapy", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY., US, vol. 33, no. 2, 1 February 2006 (2006-02-01), US , pages 271 - 279, XP005341222, ISSN: 0969-8051, DOI: 10.1016/j.nucmedbio.2005.12.004
XIE QINGHUA, ZHU HUA, WANG FENG, MENG XIANGXI, REN QIUSHI, XIA CHUANQIN, YANG ZHI: "Establishing Reliable Cu-64 Production Process: From Target Plating to Molecular Specific Tumor Micro-PET Imaging", MOLECULES, vol. 22, no. 4, 17 April 2017 (2017-04-17), XP055979116, DOI: 10.3390/molecules22040641
BOGDAN MITRAN; SARA S. RINNE; MARK W. KONIJNENBERG; THEODOSIA MAINA; BERTHOLD A. NOCK; MOHAMED ALTAI; ANZHELIKA VOROBYEVA; MATS LA: "Trastuzumab cotreatment improves survival of mice with PC‐3 prostate cancer xenografts treated with the GRPR antagonist 177Lu‐DOTAGA‐PEG2‐RM26", INTERNATIONAL JOURNAL OF CANCER, JOHN WILEY & SONS, INC., US, vol. 145, no. 12, 23 May 2019 (2019-05-23), US , pages 3347 - 3358, XP071290851, ISSN: 0020-7136, DOI: 10.1002/ijc.32401
BERNHARD ET AL.: "DOTAGA-Anhydride: A Valuable Building Block for the Preparation of DOTA-Like Chelating Agents Chem", EUR. J, vol. 18, 2012, pages 7834 - 7841, XP055465245, DOI: 10.1002/chem.201200132
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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