Title:
QUATERNARY AMMONIUM SALT COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/247914
Kind Code:
A1
Abstract:
Provided are a quaternary ammonium salt compound, a preparation method therefor and a use thereof. The compound represented by general formula (I), or an isomer or pharmaceutically acceptable salt thereof, and a composition thereof can be used for the preparation of anesthetic or analgesic drugs. Each substituent of general formula (I) is the same as in the definition of the description.
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Inventors:
ZHOU HAO (CN)
LIANG DALI (CN)
LIU ZEWEN (CN)
ZHOU XIUJIE (CN)
CHEN LEI (CN)
LIAO ZONGQUAN (CN)
LV JINLIANG (CN)
LI LIE (CN)
TIAN LUANYUAN (CN)
LIANG DALI (CN)
LIU ZEWEN (CN)
ZHOU XIUJIE (CN)
CHEN LEI (CN)
LIAO ZONGQUAN (CN)
LV JINLIANG (CN)
LI LIE (CN)
TIAN LUANYUAN (CN)
Application Number:
PCT/CN2022/095336
Publication Date:
December 01, 2022
Filing Date:
May 26, 2022
Export Citation:
Assignee:
YICHANG HUMANWELL PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D211/60; A61K31/452; A61P23/02; C07D225/02; C07D401/06
Foreign References:
| CN114075184A | 2022-02-22 | |||
| CN112574098A | 2021-03-30 | |||
| CN111153851A | 2020-05-15 | |||
| US20210107872A1 | 2021-04-15 | |||
| CN202110587550A | 2021-05-27 | |||
| CN110156665B | 2020-07-14 | |||
| CN110156666A | 2019-08-23 | |||
| CN101050200A | 2007-10-10 |
Other References:
BECKER D E. ET AL.: "Local anesthetics: review of pharmacological considerations", ANESTH PROG., vol. 59, no. 2, 2012, pages 90 - 102, XP055663072, DOI: 10.2344/0003-3006-59.2.90
COURTNEY KR: "Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA", J PHARMACOL EXP THER., vol. 195, 1975, pages 225 - 236
ALSALEM M. ET AL.: "Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat", BMC PHARMACOL TOXICOL., vol. 17, no. 1, 2016, pages 31
COURTNEY KR: "Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA", J PHARMACOL EXP THER., vol. 195, 1975, pages 225 - 236
ALSALEM M. ET AL.: "Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat", BMC PHARMACOL TOXICOL., vol. 17, no. 1, 2016, pages 31
Attorney, Agent or Firm:
AFD CHINA INTELLECTUAL PROPERTY LAW OFFICE (CN)
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