Title:
PYRAZOLONE COMPOUND AND PYRAZOLONE AGENT
Document Type and Number:
WIPO Patent Application WO/2024/024760
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a highly stable pyrazolone compound. This problem can be solved by a pyrazolone compound represented by formula (1) of the present invention (in the formula, R1 is an electron-withdrawing group selected from the group consisting of halogen atoms, nitro groups, cyano groups, haloalkyl groups having 1 to 10 carbon atoms, perfluoropolyether groups having 2 to 10 carbon atoms, carboxy groups, substituted aryl groups having 6 to 60 carbon atoms, and groups represented by formulas (2) to (7), R2 is a hydrocarbon group that has 1 to 1000 carbon atoms and may contain a heteroatom, and n is an integer of 0 to 2).
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Inventors:
OSUMI KENJI (JP)
GOTO KOHTARO (JP)
TSUTSUI MASATO (JP)
MIZUNO MAMORU (JP)
SUGI TOMOKAZU (JP)
GOTO KOHTARO (JP)
TSUTSUI MASATO (JP)
MIZUNO MAMORU (JP)
SUGI TOMOKAZU (JP)
Application Number:
PCT/JP2023/027102
Publication Date:
February 01, 2024
Filing Date:
July 25, 2023
Export Citation:
Assignee:
THE NOGUCHI INST (JP)
International Classes:
C07D231/20; C07D231/22; C07D401/04; C07D403/04; C07H1/00; C07H7/06
Domestic Patent References:
| WO2006129583A1 | 2006-12-07 | |||
| WO2006129587A1 | 2006-12-07 |
Foreign References:
| JP2009093909A | 2009-04-30 | |||
| JPH03289653A | 1991-12-19 | |||
| JPH0485538A | 1992-03-18 | |||
| JPH08229302A | 1996-09-10 | |||
| JP2003059547A | 2003-02-28 | |||
| JP2005015750A | 2005-01-20 | |||
| JPS5980470A | 1984-05-09 | |||
| CN110128345A | 2019-08-16 |
Other References:
KUDIRKA ROMAS A., BARFIELD ROBYN M., MCFARLAND JESSE M., DRAKE PENELOPE M., CARLSON ADAM, BAÑAS STEFANIE, ZMOLEK WES, GAROFALO ALB: "Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 7, no. 11, 10 November 2016 (2016-11-10), US , pages 994 - 998, XP093133609, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.6b00253
JANSON NILS, KRÜGER TOBIAS, KARSTEN LENNARD, BOSCHANSKI MAREILE, DIERKS THOMAS, MÜLLER KRISTIAN M., SEWALD NORBERT: "Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs", CHEMBIOCHEM, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 21, no. 24, 11 December 2020 (2020-12-11), Hoboken, USA, pages 3580 - 3593, XP093100013, ISSN: 1439-4227, DOI: 10.1002/cbic.202000416
ANGELASTRO ANTONIO, BARKHANSKIY ALEXEY, MATTEY ASHLEY P., PALLISTER EDWARD G., SPIESS REYNARD, GOUNDRY WILLIAM, BARRAN PERDITA, FL: "Galactose Oxidase Enables Modular Assembly of Conjugates from Native Antibodies with High Drug‐to‐Antibody Ratios**", CHEMSUSCHEM, WILEY-VCH, DE, vol. 15, no. 9, 6 May 2022 (2022-05-06), DE , XP093133611, ISSN: 1864-5631, DOI: 10.1002/cssc.202102592
JANSON NILS, KRÜGER TOBIAS, KARSTEN LENNARD, BOSCHANSKI MAREILE, DIERKS THOMAS, MÜLLER KRISTIAN M., SEWALD NORBERT: "Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs", CHEMBIOCHEM, JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 21, no. 24, 11 December 2020 (2020-12-11), Hoboken, USA, pages 3580 - 3593, XP093100013, ISSN: 1439-4227, DOI: 10.1002/cbic.202000416
ANGELASTRO ANTONIO, BARKHANSKIY ALEXEY, MATTEY ASHLEY P., PALLISTER EDWARD G., SPIESS REYNARD, GOUNDRY WILLIAM, BARRAN PERDITA, FL: "Galactose Oxidase Enables Modular Assembly of Conjugates from Native Antibodies with High Drug‐to‐Antibody Ratios**", CHEMSUSCHEM, WILEY-VCH, DE, vol. 15, no. 9, 6 May 2022 (2022-05-06), DE , XP093133611, ISSN: 1864-5631, DOI: 10.1002/cssc.202102592
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
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