Title:
PRODUCTION METHOD FOR TAFAMIDIS OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/019180
Kind Code:
A1
Abstract:
The present invention provides a method with which it is possible to produce tafamidis or a salt thereof with high yield. This production method for tafamidis or a salt thereof comprises a cyclization step for obtaining a compound represented by formula (2) by cyclization of a compound represented by formula (1) in the presence of an amine ligand, a base, and at least one copper catalyst selected from among copper halides, copper carboxylates, copper sulfates, and copper oxides. [In formula (1), R1 represents a linear or branched alkyl group, and X represents a halogen atom.] [In formula (2), R1 is the same as defined above.]
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Inventors:
YOSHINO HIROSHI (JP)
SHIRO YUICHI (JP)
KIMURA YU (JP)
SHIRO YUICHI (JP)
KIMURA YU (JP)
Application Number:
PCT/JP2023/027059
Publication Date:
January 25, 2024
Filing Date:
July 24, 2023
Export Citation:
Assignee:
SHIRATORI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D263/57
Domestic Patent References:
| WO2021152623A1 | 2021-08-05 |
Foreign References:
| JP2021517118A | 2021-07-15 |
Other References:
SHI YAJIE; ZHOU QIFAN; DU FANGYU; FU YANG; DU YANG; FANG TING; CHEN GUOLIANG: "Iridium-catalyzed intramolecular CN and CO/S cross-coupling reactions: Preparation of benzoazole derivatives", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 60, no. 40, 26 August 2019 (2019-08-26), Amsterdam , NL , XP085829588, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2019.151082
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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