Title:
PRODUCTION METHOD FOR ETHYL 8-CHLOROOCTANOATE
Document Type and Number:
WIPO Patent Application WO/2024/077796
Kind Code:
A1
Abstract:
Disclosed is a production method for ethyl 8-chlorooctanoate in the field of medicine or pesticide manufacturing. A dual catalyst containing potassium bromide or sodium bromide and polyethylene glycol is used, and an alkylation reaction is carried out by corresponding 1,6-dichlorohexane and diethyl malonate in the presence of potassium carbonate. After the reaction ends, a crude product of diethyl 6-chlorohexyl malonate is obtained by distillation, and then under the catalysis of a sulfonic acid, a one-pot method is used to complete hydrolysis and decarboxylation, distillation under reduced pressure to remove water, and ethanol esterification, and finally rectification is performed to obtain high-purity ethyl 8-chlorooctanoate, which can meet the needs of customers. The present method simplifies production operations, shortens unit operation time, reduces labor intensity, and improves product quality.
Inventors:
QU JUN (CN)
HU ZHONG (CN)
GAO DEHUA (CN)
WU HONGXIANG (CN)
ZHANG PENGCHENG (CN)
XUE HONGLAN (CN)
HU ZHONG (CN)
GAO DEHUA (CN)
WU HONGXIANG (CN)
ZHANG PENGCHENG (CN)
XUE HONGLAN (CN)
Application Number:
PCT/CN2022/143964
Publication Date:
April 18, 2024
Filing Date:
December 30, 2022
Export Citation:
Assignee:
YANGZHOU PRINCECHEM CO LTD (CN)
International Classes:
C07C67/343; C07C51/09; C07C53/19; C07C67/08; C07C69/34; C07C69/63
Foreign References:
| CN101328120A | 2008-12-24 | |||
| CN105566111A | 2016-05-11 | |||
| CN113087623A | 2021-07-09 | |||
| US20040054226A1 | 2004-03-18 |
Attorney, Agent or Firm:
NANJING SUKE PATENT AGENT CO., LTD. et al. (CN)
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