Title:
PREPARATION METHOD FOR POLYETHYLENE GLYCOL CONJUGATE OF ACTIVE POLYPEPTIDE OR PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/017379
Kind Code:
A1
Abstract:
A preparation method for a polyethylene glycol conjugate of an active polypeptide or protein, comprising a step of mixing an active polypeptide or protein with polyethylene glycol and reacting same, wherein the polyethylene glycol contains a single active functional group which is not linked to a non-polyethylene glycol original functional structure in advance, and in a reaction liquid of the reaction, the total concentration of a conjugate acid-base pair is 0.13-5.5 M. The degree of modification is improved by means of increasing the ionic strength, and furthermore, the activity of the polypeptide or protein is not obviously reduced as the degree of modification increases.
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Inventors:
XU MICHAEL MIN (CN)
ZHANG YINGHUI (CN)
ZHANG YINGHUI (CN)
Application Number:
PCT/CN2023/108707
Publication Date:
January 25, 2024
Filing Date:
July 21, 2023
Export Citation:
Assignee:
PEGBIO CO LTD (CN)
International Classes:
C07K1/107; A61K38/44; A61K47/60; C12N9/96; C12N11/08
Foreign References:
| CN114438047A | 2022-05-06 | |||
| CN101928704A | 2010-12-29 | |||
| CN105820232A | 2016-08-03 | |||
| CN1561390A | 2005-01-05 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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