Title:
PREPARATION METHOD FOR MIGLITTOL
Document Type and Number:
WIPO Patent Application WO/2023/138099
Kind Code:
A1
Abstract:
The present invention relates to a preparation method for miglitol. Specifically, the method of the present invention comprises: using a compound represented by formula VI as a raw material, subjecting the raw material to sulfonylation and then to a substitution reaction with ethanolamine, then removing a protecting group, and finally carrying out hydrogenation and cyclization to prepare miglitol. The method of the present invention has the advantages of simple steps, mild reaction conditions, high total yield, high product purity and the like, and is very suitable for industrial production.
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Inventors:
DAI CHUNGUANG (CN)
LI YUNFENG (CN)
PU XUECAN (CN)
SONG ZONGSHENG (CN)
ZHANG LIRONG (CN)
ZHENG ZHIGUO (CN)
LI YUNFENG (CN)
PU XUECAN (CN)
SONG ZONGSHENG (CN)
ZHANG LIRONG (CN)
ZHENG ZHIGUO (CN)
Application Number:
PCT/CN2022/122535
Publication Date:
July 27, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
ZHEJIANG AUSUN PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D211/46; C07H1/00; C07H15/12; C07H15/18; C07H23/00
Foreign References:
| CN114516831A | 2022-05-20 | |||
| CN112142648A | 2020-12-29 | |||
| CN105968042A | 2016-09-28 | |||
| US4429117A | 1984-01-31 | |||
| US4405714A | 1983-09-20 |
Other References:
BOUCHERON, C. DESVERGNES, V. COMPAIN, P. MARTIN, O.R. LAVI, A. MACKEEN, M. WORMALD, M. DWEK, R. BUTTERS, T.D.: "Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 16, no. 10, 23 May 2005 (2005-05-23), OXFORD, GB , pages 1747 - 1756, XP004899754, ISSN: 0957-4166, DOI: 10.1016/j.tetasy.2005.03.015
BOUCHERON, C. COMPAIN, P. MARTIN, O.R.: "A stereodivergent approach to 1-deoxynojirimycin, 1-deoxygalactonojirimycin and 1-deoxymannojirimycin derivatives", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 47, no. 18, 1 May 2006 (2006-05-01), Amsterdam , NL , pages 3081 - 3084, XP005361905, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2006.02.157
TIAN LILI, LI ZHONG-JUN, LI HUI: "Synthesis of Deoxynojirimycin（DNJ）", CHINESE JOURNAL OF APPLIED CHEMISTRY - YINGYONG HUAXUE, KEXUE CHUBANSHE, CN, vol. 21, no. 1, 31 January 2004 (2004-01-31), CN , pages 12 - 15, XP093079452, ISSN: 1000-0518
ELISA DANIELI ET AL.: "Selective protecting group manipulations on the 1-deoxynojirimycin scaffold", TETRAHEDRON, vol. 63, no. 29, 25 April 2007 (2007-04-25), pages 6827 - 6834, XP022107495, ISSN: 0040-4020, DOI: 10.1016/j.tet.2007.04.070
BOUCHERON, C. COMPAIN, P. MARTIN, O.R.: "A stereodivergent approach to 1-deoxynojirimycin, 1-deoxygalactonojirimycin and 1-deoxymannojirimycin derivatives", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 47, no. 18, 1 May 2006 (2006-05-01), Amsterdam , NL , pages 3081 - 3084, XP005361905, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2006.02.157
TIAN LILI, LI ZHONG-JUN, LI HUI: "Synthesis of Deoxynojirimycin（DNJ）", CHINESE JOURNAL OF APPLIED CHEMISTRY - YINGYONG HUAXUE, KEXUE CHUBANSHE, CN, vol. 21, no. 1, 31 January 2004 (2004-01-31), CN , pages 12 - 15, XP093079452, ISSN: 1000-0518
ELISA DANIELI ET AL.: "Selective protecting group manipulations on the 1-deoxynojirimycin scaffold", TETRAHEDRON, vol. 63, no. 29, 25 April 2007 (2007-04-25), pages 6827 - 6834, XP022107495, ISSN: 0040-4020, DOI: 10.1016/j.tet.2007.04.070
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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